Li Jie, Shao Xiaoqian, Yu Rongling, Shi Lingyun, Xu Dejing, Yu Xiaoyan
Jie Li, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu & Jiangsu Institute of Cancer, Research & Cancer Nursing Research Sub-Center, Nursing, Research Center of Nanjing Medical University, Nanjing 210009, Jiangsu Province, P.R. China.
Xiaoqian Shao, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu & Jiangsu Institute of Cancer, Research & Cancer Nursing Research Sub-Center, Nursing, Research Center of Nanjing Medical University, Nanjing 210009, Jiangsu Province, P.R. China.
Pak J Med Sci. 2023 Nov-Dec;39(6):1751-1756. doi: 10.12669/pjms.39.6.7830.
To investigate patient-reported outcomes of taste alterations and quality of life (QoL) in patients with nasopharyngeal carcinoma (NPC).
In this single-center retrospective study medical records of 191 patients with NPC undergoing chemoradiotherapy (CRT) in the Department of Radiotherapy, Jiangsu Cancer Hospital, the Affiliated Cancer Hospital of Nanjing Medical University from January 2021 to December 2021 were reviewed. A total of 120 patients met eligibility criteria and were included. The taste alterations and QoL at multiple time points during radiotherapy (RT) were compared.
There were significant differences in the intensity of taste, discomfort, phantogeusia and parageusia or overall taste alterations at multiple time points during CRT (p-Value<0.001). These four parameters were significantly higher two or four weeks after CRT, or at the end of CRT compared to before CRT (p-Value <0.001). The intensity of taste, discomfort, phantogeusia and parageusia or overall taste alterations were all significantly higher four weeks after CRT compared to two weeks after CRT (p-Value <0.001), and at the end of CRT compared to four weeks after CRT (p-Value <0.001). The chemotherapy-induced taste alteration scale (CiTAS) scores were highest at the end of CRT (p-Value <0.001). There were significant differences in QoL at multiple time points during CRT (p-Value <0.001), and each parameter differed significantly at various time points (p <0.05). The QoL of all areas at the end of CRT were significantly higher than those before CRT, or two or four weeks after CRT (p-Value <0.001).
In patients with NPC undergoing CRT, taste alterations increasingly worsen as treatment progresses, with poor QoL outcomes.
探讨鼻咽癌（NPC）患者报告的味觉改变及生活质量（QoL）情况。
在这项单中心回顾性研究中，回顾了2021年1月至2021年12月在南京医科大学附属肿瘤医院江苏省肿瘤医院放疗科接受放化疗（CRT）的191例NPC患者的病历。共有120例患者符合纳入标准并被纳入研究。比较了放疗（RT）期间多个时间点的味觉改变和生活质量。
在CRT期间的多个时间点，味觉强度、不适感、幻味和异味或总体味觉改变方面存在显著差异（p值<0.001）。与CRT前相比，这四个参数在CRT后两周或四周时，或在CRT结束时显著更高（p值<0.001）。与CRT后两周相比，CRT后四周时的味觉强度、不适感、幻味和异味或总体味觉改变均显著更高（p值<0.001），且与CRT后四周相比，CRT结束时这些指标也显著更高（p值<0.001）。化疗引起的味觉改变量表（CiTAS）评分在CRT结束时最高（p值<0.001）。CRT期间多个时间点的生活质量存在显著差异（p值<0.001），且各参数在不同时间点均有显著差异（p<0.05）。CRT结束时所有领域的生活质量均显著高于CRT前、或CRT后两周或四周时（p值<0.001）。
接受CRT的NPC患者，随着治疗进展，味觉改变日益恶化，生活质量较差。
