乌帕替尼在难治性食管扁平苔藓中的应用：“扁平苔藓”视野下的内镜改善
Use of Upadacitinib in Refractory Esophageal Lichen Planus: Endoscopic Improvement in "Planus" Sight.
作者信息
Becker Erica C, Mavilia-Scranton Marianna, Finch Justin, Yu Mingfu, Rezaizadeh Houman
机构信息
Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT.
Department of Gastroenterology, University of Connecticut Health Center, Farmington, CT.
出版信息
ACG Case Rep J. 2023 Nov 4;10(11):e01200. doi: 10.14309/crj.0000000000001200. eCollection 2023 Nov.
Although rarely reported, esophageal lichen planus is a chronic inflammatory disease that can lead to debilitating symptoms. It is reported to affect adult women in the fourth and fifth decades of life. Treatment ranges from medical therapy to endoscopic dilation. Owing to underdiagnoses and limited data on therapies, little guidance is provided in the literature regarding treatment of refractory cases. We report a case of a 68-year-old woman with esophageal lichen planus who had symptoms and lack of histological improvement despite being on budesonide and mycophenolate. She was then transitioned to upadacitinib 30 mg daily and had significant symptomatic and endoscopic improvement.
尽管食管扁平苔藓鲜有报道，但它是一种可导致使人衰弱症状的慢性炎症性疾病。据报道，该病会影响处于四五十岁年龄段的成年女性。治疗方法从药物治疗到内镜扩张不等。由于诊断不足以及关于治疗的数据有限，文献中对于难治性病例的治疗几乎没有提供指导。我们报告一例68岁患有食管扁平苔藓的女性病例，尽管使用了布地奈德和霉酚酸酯，但她仍有症状且组织学上没有改善。随后她改用乌帕替尼，每日30毫克，症状和内镜检查结果都有显著改善。
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