Department of Surgery, University of Valladolid, Valladolid, Spain; Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain.
Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain; Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain.
Biochim Biophys Acta Mol Basis Dis. 2024 Feb;1870(2):166946. doi: 10.1016/j.bbadis.2023.166946. Epub 2023 Nov 7.
Sepsis is the most common cause of death from infection in the world. Unfortunately, there is no specific treatment for patients with sepsis, and management relies on infection control and support of organ function. A better understanding of the underlying pathophysiology of this syndrome will help to develop innovative therapies. In this regard, it has been widely reported that endothelial cell activation and dysfunction are major contributors to the development of sepsis. This review aims to provide a comprehensive overview of emerging findings highlighting the prominent role of mitochondria in the endothelial response in in vitro experimental models of sepsis. Additionally, we discuss potential mitochondrial targets that have demonstrated protective effects in preclinical investigations against sepsis. These promising findings hold the potential to pave the way for future clinical trials in the field.
败血症是世界上感染导致死亡的最常见原因。不幸的是，败血症患者没有特定的治疗方法，其治疗主要依赖于感染控制和器官功能支持。更好地了解这种综合征的潜在病理生理学机制将有助于开发创新疗法。在这方面，已经广泛报道内皮细胞的激活和功能障碍是败血症发展的主要原因。这篇综述旨在提供一个全面的概述，强调线粒体在败血症体外实验模型中内皮反应中的突出作用。此外，我们还讨论了在败血症的临床前研究中具有保护作用的潜在线粒体靶点。这些有前景的发现为该领域的未来临床试验铺平了道路。
