Gabriele F, Ecca A R, Wakelin D, Palmas C
J Helminthol. 1986 Dec;60(4):313-21. doi: 10.1017/s0022149x00008555.
The kinetics of the lymphoblast response in mice during the course of a primary infection with Hymenolepis nana was measured by the in vivo uptake of 125IUdR. The response was most marked in tissues local to the site of infection, involving the nodes draining the small intestine but not other areas, e.g., inguinal lymph nodes. A close correlation between these responses and the course of infection was observed. Uptake of 125IUdR was greatest in the mesenteric lymph node (MLN) but the peak reached in this organ was later than that in Peyer's patches (PP), small intestine (SI) and spleen (S). The increase in lymphoblast activity of the MLN was similar with Trichinella spiralis; no significant blast cell response to infection with H. diminuta was found till day 9 after injection, the results being similar to those obtained when H. nana infections were established using cysticercoids rather than eggs. It has been shown that the increase in lymphoblast activity was closely correlated with the presence of cells which are most effective in adoptive transfer immunity. A dose-dependent effect was detected in blast cell activity of MLN in different infection levels with T. spiralis and H. nana.
通过体内摄取¹²⁵IUdR来测定小鼠在初次感染微小膜壳绦虫过程中淋巴母细胞反应的动力学。该反应在感染部位的局部组织中最为明显，涉及引流小肠的淋巴结，但不包括其他区域，如腹股沟淋巴结。观察到这些反应与感染过程密切相关。¹²⁵IUdR在肠系膜淋巴结（MLN）中的摄取量最大，但该器官达到的峰值晚于派尔集合淋巴结（PP）、小肠（SI）和脾脏（S）。MLN的淋巴母细胞活性增加与旋毛虫感染时相似；在注射后第9天之前，未发现对缩小膜壳绦虫感染有明显的母细胞反应，结果与使用似囊尾蚴而非虫卵建立微小膜壳绦虫感染时获得的结果相似。研究表明，淋巴母细胞活性的增加与在过继转移免疫中最有效的细胞的存在密切相关。在不同感染水平的旋毛虫和微小膜壳绦虫感染中，检测到MLN母细胞活性存在剂量依赖性效应。
