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糖皮质激素信号转导及高脂饮食对体内脂肪生成的影响。

Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo.

机构信息

Department of Pediatrics, Division of Endocrinology, University of California, San Francisco (UCSF), San Francisco, CA, United States.

Department of Pediatrics, Division of Endocrinology, University of California, San Francisco (UCSF), San Francisco, CA, United States.

出版信息

Steroids. 2024 Jan;201:109336. doi: 10.1016/j.steroids.2023.109336. Epub 2023 Nov 7.

DOI:10.1016/j.steroids.2023.109336
PMID:37944652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11005958/
Abstract

Our research used glucocorticoids as a medically relevant molecular probe to identify a previously unrecognized ADAMTS1-PTN-Wnt pathway. We elucidated the role of this pathway in regulating adipose precursor cell (APC) behavior to either proliferate or differentiate in response to systemic cues, such as elevated caloric intake. Further, our studies identified the non-muscle myosin protein MYH9 as a key target of this pathway to modulate adipogenesis in vivo. These findings enable strategies toward developing novel therapeutics for obesity and related metabolic disorders.

摘要

我们的研究使用糖皮质激素作为医学相关的分子探针，以确定以前未被识别的 ADAMTS1-PTN-Wnt 途径。我们阐明了该途径在调节脂肪前体细胞 (APC) 行为中的作用，使其能够响应全身性信号（如高热量摄入）增殖或分化。此外，我们的研究确定了非肌肉肌球蛋白蛋白 MYH9 是该途径调节体内脂肪生成的关键靶点。这些发现为开发治疗肥胖症和相关代谢紊乱的新型疗法提供了策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d9/11005958/0a35b14a5e63/nihms-1980411-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d9/11005958/0a35b14a5e63/nihms-1980411-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d9/11005958/0a35b14a5e63/nihms-1980411-f0001.jpg

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本文引用的文献

1
Adipose tissue expansion in obesity, health, and disease.肥胖、健康与疾病状态下的脂肪组织扩张
Front Cell Dev Biol. 2023 Apr 26;11:1188844. doi: 10.3389/fcell.2023.1188844. eCollection 2023.
2
MYH10 Governs Adipocyte Function and Adipogenesis through Its Interaction with GLUT4.MYH10 通过与 GLUT4 相互作用来调节脂肪细胞功能和脂肪生成。
Int J Mol Sci. 2022 Feb 21;23(4):2367. doi: 10.3390/ijms23042367.
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The Potential to Fight Obesity with Adipogenesis Modulating Compounds.用脂肪生成调节化合物对抗肥胖的潜力。
Int J Mol Sci. 2022 Feb 19;23(4):2299. doi: 10.3390/ijms23042299.
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Resident and migratory adipose immune cells control systemic metabolism and thermogenesis.驻留和迁移的脂肪组织免疫细胞控制全身代谢和产热。
Cell Mol Immunol. 2022 Mar;19(3):421-431. doi: 10.1038/s41423-021-00804-7. Epub 2021 Nov 26.
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MYH9 is crucial for stem cell-like properties in non-small cell lung cancer by activating mTOR signaling.MYH9通过激活mTOR信号传导对非小细胞肺癌中的干细胞样特性至关重要。
Cell Death Discov. 2021 Oct 11;7(1):282. doi: 10.1038/s41420-021-00681-z.
6
MYH9 facilitates autoregulation of adipose tissue depot development.MYH9 促进脂肪组织库发育的自身调控。
JCI Insight. 2021 May 10;6(9):136233. doi: 10.1172/jci.insight.136233.
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Pleiotrophin: Activity and mechanism.pleiotrophin：活性与机制。
Adv Clin Chem. 2020;98:51-89. doi: 10.1016/bs.acc.2020.02.003. Epub 2020 Mar 12.
8
Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: Therapeutic targets for obesity and type 2 diabetes.Wnt 信号转导介导 TLR 通路，促进无限制的脂肪生成和代谢炎症：肥胖症和 2 型糖尿病的治疗靶点。
Pharmacol Res. 2020 Feb;152:104602. doi: 10.1016/j.phrs.2019.104602. Epub 2019 Dec 14.
9
The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor.糖皮质激素受体介导的间充质干细胞成骨细胞生成和脂肪生成之间平衡的转变。
Stem Cell Res Ther. 2019 Dec 5;10(1):377. doi: 10.1186/s13287-019-1498-0.
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Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications.脂肪组织功能障碍作为肥胖相关代谢并发症的决定因素。
Int J Mol Sci. 2019 May 13;20(9):2358. doi: 10.3390/ijms20092358.