Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Clin Obes. 2024 Apr;14(2):e12627. doi: 10.1111/cob.12627. Epub 2023 Nov 9.
Obesity, especially central obesity is associated with increased risk of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus. The study aimed to investigate the associations of the changes of abdominal fat thicknesses with changes of anthropometric indexes and improvements of metabolic phenotypes in patients with obesity and T2DM before and after bariatric surgery. Between April 2016 and January 2017, 34 adult patients with concurrent obesity and T2DM scheduled for different bariatric surgeries were prospectively evaluated by ultrasound before and 1-year after bariatric surgery to determine abdominal fat thicknesses (mesenteric fat, preperitoneal fat and subcutaneous fat) and NAFLD. At 1 year, of the 25 patients that finished the study, significant decrease in mesenteric-fat-thickness was associated with significant reduction of obesity, that is, BMI (-24%, p < .001), remission of metabolic syndrome (32%, p = .008), NAFLD (60%, p < .001) and T2DM (44%, p < .001). Lower baseline mesenteric fat thickness was associated with remission of metabolic syndrome. Lower baseline mesenteric-fat-thickness may have the potential to predict metabolic syndrome remission after bariatric surgery.
肥胖，尤其是中心型肥胖与代谢综合征、非酒精性脂肪性肝病（NAFLD）和 2 型糖尿病的风险增加有关。本研究旨在探讨肥胖和 2 型糖尿病患者在减重手术后，腹部脂肪厚度变化与人体测量指标变化和代谢表型改善的相关性。2016 年 4 月至 2017 年 1 月，前瞻性评估了 34 例同时患有肥胖和 2 型糖尿病并计划接受不同减重手术的成年患者，通过超声检查在减重手术前和 1 年后测量腹部脂肪厚度（肠系膜脂肪、腹膜前脂肪和皮下脂肪）和 NAFLD。在 1 年后完成研究的 25 例患者中，肠系膜脂肪厚度的显著下降与肥胖的显著减轻相关，即 BMI（-24%，p<0.001）、代谢综合征的缓解（32%，p=0.008）、NAFLD（60%，p<0.001）和 2 型糖尿病（44%，p<0.001）。较低的基线肠系膜脂肪厚度与代谢综合征的缓解相关。较低的基线肠系膜脂肪厚度可能有潜力预测减重手术后代谢综合征的缓解。
