Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Department of Medical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Surg Oncol Clin N Am. 2024 Jan;33(1):173-195. doi: 10.1016/j.soc.2023.06.012. Epub 2023 Aug 25.
Hepatocellular carcinoma (HCC)is a common type of liver cancer with a poor prognosis, especially in patients with advanced stages or underlying liver disease. While surgical resection, liver transplantation, and ablation therapies have traditionally been the mainstay of treatment for HCC, radiation therapy has become increasingly recognized as an effective alternative, particularly for those who are not surgical candidates. Stereotactic Body Radiation Therapy (SBRT) is a highly precise form of radiation therapy that delivers very high doses of radiation to the tumor while sparing surrounding healthy tissue. Several studies have reported favorable outcomes with SBRT in HCC treatment. Moreover, SBRT can be used to treat recurrent HCC after prior treatment, offering a potentially curative approach in select cases. While SBRT has demonstrated its efficacy and safety in treating HCC, future studies are needed to further investigate the potential role of SBRT in combination with other treatments for HCC.
肝细胞癌（HCC）是一种常见的肝癌类型，预后较差，尤其是在晚期或存在基础肝病的患者中。尽管手术切除、肝移植和消融治疗一直是 HCC 的主要治疗方法，但放射治疗已越来越被认为是一种有效的替代方法，特别是对于那些不适合手术的患者。立体定向体部放射治疗（SBRT）是一种高度精确的放射治疗方法，可向肿瘤提供非常高剂量的辐射，同时保护周围的健康组织。几项研究报告了 SBRT 在 HCC 治疗中的良好结果。此外，SBRT 可用于治疗先前治疗后的复发性 HCC，在某些情况下提供潜在的治愈方法。虽然 SBRT 在治疗 HCC 方面已显示出其疗效和安全性，但仍需要进一步的研究来探讨 SBRT 与其他 HCC 治疗方法联合应用的潜在作用。
