Endrocrinology, Hospital Universitario Nacional de Colombia, Bogota, Colombia.
Endocrinology, Hospital Militar Central, Bogotá, Colombia
BMJ Case Rep. 2023 Nov 9;16(11):e257200. doi: 10.1136/bcr-2023-257200.
The presence of mature bone and bone marrow in the thyroid gland is an exceedingly rare occurrence. Extramedullary haematopoiesis (EMH) and heterotopic bone formation (HBF) should be suspected when cytology of thyroid nodules reveals evidence of megakaryocytes or bone marrow fat, respectively. The cause of these abnormalities has not been fully elucidated, but the role of bone morphogenic factors (BMPs) in their pathogenesis has been suggested. Both EMH and HBF can be seen in both benign and malignant primary thyroid conditions, and although they have not been definitively associated with significant pathology, it is recommended that extension studies be considered in the event of these findings to rule out concomitant haematological conditions.
甲状腺中存在成熟的骨和骨髓是极其罕见的。当甲状腺结节的细胞学检查显示巨核细胞或骨髓脂肪时，应怀疑骨髓外造血（EMH）和异位骨形成（HBF）。这些异常的原因尚未完全阐明，但骨形态发生因子（BMPs）在其发病机制中的作用已被提出。EMH 和 HBF 均可在良性和恶性原发性甲状腺疾病中见到，尽管它们与显著的病理学尚未明确相关，但建议在发现这些情况时考虑进行扩展研究以排除伴随的血液学疾病。
