Hogan B L, Horsburgh G, Cohen J, Hetherington C M, Fisher G, Lyon M F
J Embryol Exp Morphol. 1986 Sep;97:95-110.
Small eyes (Sey) is a semidominant, homozygous lethal mutation in the mouse (Roberts, 1967). It is allelic with SeyH, a radiation-induced homozygous prenatal lethal which has been mapped on chromosome 2. The effect of the Sey mutation is apparently limited to the growth and differentiation of the presumptive lens and nasal placodes. Homozygous Sey/Sey embryos can be distinguished as early as 10.5 days post coitum (p.c.); the optic vesicles grow out, but the ectoderm does not give rise to a lens and nasal pits never form. Immunohistochemical studies show that the distribution of the extracellular matrix glycoprotein laminin is not significantly different in the cephalic region of Sey/Sey versus Sey/+ or +/+ embryos. Sey/Sey embryos develop to term but without eyes or nose, and die soon after birth. Further analysis of Sey/Sey embryos may throw light on the mechanisms underlying morphogenesis of craniofacial structures in mammals.
小眼（Sey）是小鼠中的一种半显性纯合致死突变（罗伯茨，1967年）。它与SeyH等位，SeyH是一种辐射诱导的纯合产前致死突变，已定位在2号染色体上。Sey突变的影响显然仅限于假定晶状体和鼻基板的生长和分化。纯合的Sey/Sey胚胎在交配后10.5天（p.c.）就可以被区分出来；视泡生长出来，但外胚层不会形成晶状体，鼻凹也永远不会形成。免疫组织化学研究表明，细胞外基质糖蛋白层粘连蛋白在Sey/Sey胚胎与Sey/+或+/+胚胎头部区域的分布没有显著差异。Sey/Sey胚胎发育至足月，但没有眼睛或鼻子，出生后不久就会死亡。对Sey/Sey胚胎的进一步分析可能会揭示哺乳动物颅面结构形态发生的潜在机制。
