Amna Touseef, Hassan M Shamshi
Department of Biology, College of Science, Al-Baha University, Albaha 65799, Saudi Arabia.
Department of Chemistry, College of Science, Al-Baha University, Albaha 65799, Saudi Arabia.
Nanomaterials (Basel). 2023 Oct 31;13(21):2891. doi: 10.3390/nano13212891.
Antibiotic resistance is rising and poses a serious threat to human health on a worldwide scale. It can make it more difficult to cure common infections, raise medical expenditures, and increase mortality. In order to combat the development of biofilms and treat fatal bacterial infections, multifunctional polymeric nanofibers or nanotextured materials with specific structural features and special physiochemical capabilities have become a crucial tool. Due to the increased antibiotic resistance of many diseases, nanofibers with antibacterial activity are essential. Electrospinning is a flexible process able to produce fine fibers with specified properties by modifying variables such as the concentration of the solution, the feed flow, and the electric voltage. Substantial advancements have been made regarding the formation of nanofibers or nanotextured materials for a variety of applications, along with the development of electrospinning techniques in recent years. Using well-defined antimicrobial nanoparticles, encapsulating traditional therapeutic agents, plant-based bioactive agents, and pure compounds in polymer nanofibers has resulted in outstanding antimicrobial activity and has aided in curing deadly microbial infections. A plethora of studies have revealed that electrospinning is an effective technique for the production of antimicrobial fibers for the environmental, biomedical, pharmaceutical, and food sectors. Nevertheless, numerous studies have also demonstrated that the surface characteristics of substrates, such as holes, fibers, and ridges at the nanoscale, have an impact on cell proliferation, adhesion, and orientation.
抗生素耐药性正在上升，在全球范围内对人类健康构成严重威胁。它会使常见感染更难治愈，增加医疗支出，并提高死亡率。为了对抗生物膜的形成并治疗致命的细菌感染，具有特定结构特征和特殊物理化学能力的多功能聚合物纳米纤维或纳米纹理材料已成为一种关键工具。由于许多疾病的抗生素耐药性增加，具有抗菌活性的纳米纤维至关重要。静电纺丝是一种灵活的工艺，能够通过改变溶液浓度、进料流量和电压等变量来生产具有特定性能的细纤维。近年来，随着静电纺丝技术的发展，在用于各种应用的纳米纤维或纳米纹理材料的形成方面取得了重大进展。将定义明确的抗菌纳米颗粒、传统治疗剂、植物源生物活性剂和纯化合物封装在聚合物纳米纤维中，已产生了出色的抗菌活性，并有助于治愈致命的微生物感染。大量研究表明，静电纺丝是一种用于生产环境、生物医学、制药和食品领域抗菌纤维的有效技术。然而，许多研究也表明，纳米级的基材表面特征，如孔洞、纤维和脊，会影响细胞增殖、粘附和取向。
