内源性代谢物与衰老和疾病中的基因组不稳定性。
Endogenous Metabolites and Genome Instability in Aging and Disease.
机构信息
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66044, United States.
出版信息
Chem Res Toxicol. 2023 Dec 18;36(12):1830-1833. doi: 10.1021/acs.chemrestox.3c00288. Epub 2023 Nov 10.
Abstract
Proper maintenance of genomic DNA is upheld by tight control of cellular metabolism and DNA processing. Herein, we review recent advances in examining the role of endogenous metabolites and genomic instability in aging and disease as presented at the Fall 2023 American Chemical Society Meeting.
摘要
基因组 DNA 的正常维护依赖于细胞代谢和 DNA 处理的严格控制。在此，我们回顾了在 2023 年秋季美国化学学会会议上介绍的关于内源性代谢物和基因组不稳定性在衰老和疾病中的作用的最新进展。
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