Department of Physiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
J Biochem. 2024 Feb 25;175(2):141-146. doi: 10.1093/jb/mvad089.
Cellular zoning or partitioning is critical in preventing macromolecules from random diffusion and orchestrating the spatiotemporal dynamics of biochemical reactions. Along with membranous organelles, membraneless organelles contribute to the precise regulation of biochemical reactions inside cells. In response to environmental cues, membraneless organelles rapidly form through liquid-liquid phase separation, sequester certain proteins and RNAs, mediate specific reactions and dissociate. Among membraneless organelles, ubiquitin-positive condensates, namely, p62 bodies, maintain cellular homeostasis through selective autophagy of themselves to contribute to intracellular quality control. p62 bodies also activate the anti-oxidative stress response regulated by the KEAP1-NRF2 system. In this review, we present an overview of recent advancements in cellular and molecular biology related to p62 bodies, highlighting their dynamic nature and functions.
细胞区室化或分隔对于防止大分子随机扩散和协调生化反应的时空动力学至关重要。除了膜细胞器外，无膜细胞器有助于细胞内生化反应的精确调节。无膜细胞器通过液-液相分离迅速形成，隔离某些蛋白质和 RNA，介导特定反应并解离。在无膜细胞器中，泛素阳性凝聚物，即 p62 体，通过自噬选择性地维持细胞内稳态，有助于细胞内质量控制。p62 体还激活由 KEAP1-NRF2 系统调节的抗氧化应激反应。在这篇综述中，我们介绍了与 p62 体相关的细胞和分子生物学的最新进展，强调了它们的动态性质和功能。
