Department of Physiology, Juntendo University School of Medicine, Tokyo, Japan.
IUBMB Life. 2022 Dec;74(12):1200-1208. doi: 10.1002/iub.2689. Epub 2022 Nov 17.
When p62/Sequestosome-1 binds to a ubiquitinated protein, it undergoes liquid-liquid phase separation (LLPS) and forms a membraneless organelle, p62 body. There are two major physiological functions of the p62 body. One is effective autophagic degradation of ubiquitinated proteins and the other is antioxidant stress response, both of which contribute to cellular homeostasis. In this review, I review the history of p62 research in relation to autophagy and outline the formation, degradation, and physiological functions of the p62 body.
当 p62/自噬体相关蛋白 1（Sequestosome-1）与泛素化蛋白结合时，它会发生液-液相分离（LLPS）并形成无膜细胞器 p62 体。p62 体具有两个主要的生理功能。一个是有效降解泛素化蛋白的自噬作用，另一个是抗氧化应激反应，这两者都有助于细胞内的稳态。在这篇综述中，我回顾了与自噬相关的 p62 研究历史，并概述了 p62 体的形成、降解和生理功能。
