Facultad de Medicina y Ciencia, Universidad San Sebastián, Lago Panguipulli 1390, 5501842, Puerto Montt, Chile.
Department of Neurosciences. Biomedical Neuroscience Institute, Physiology and Biophysics Program, Institute of Biomedical Sciences, Center for Exercise, Metabolism and Cancer Studies, Faculty of Medicine, Universidad de Chile, Santiago, 8380000, Chile.
Cell Calcium. 2023 Dec;116:102821. doi: 10.1016/j.ceca.2023.102821. Epub 2023 Nov 4.
Ryanodine receptors (RyR) are intracellular Ca channels localized in the endoplasmic reticulum, where they act as critical mediators of Ca-induced Ca calcium release (CICR). In the brain, mammals express in both neurons, and non-neuronal cells, a combination of the three RyR-isoforms (RyR1-3). Pharmacological approaches, which do not distinguish between isoforms, have indicated that RyR-isoforms contribute to brain function. However, isoform-specific manipulations have revealed that RyR-isoforms display different subcellular localizations and are differentially associated with neuronal function. These findings raise the need to understand RyR-isoform specific transcriptional regulation, as this knowledge will help to elucidate the causes of neuronal dysfunction for a growing list of brain disorders that show altered RyR channel expression and function.
兰尼碱受体（RyR）是定位于内质网的细胞内 Ca 通道，它们作为 Ca 诱导的 Ca 释放（CICR）的关键介质发挥作用。在大脑中，哺乳动物在神经元和非神经元细胞中表达三种 RyR 同工型（RyR1-3）的组合。不区分同工型的药理学方法表明 RyR 同工型有助于脑功能。然而，同工型特异性操作表明 RyR 同工型显示不同的亚细胞定位，并且与神经元功能的相关性不同。这些发现提出了需要了解 RyR 同工型特异性转录调控的必要性，因为这方面的知识将有助于阐明越来越多的脑疾病中神经元功能障碍的原因，这些疾病表现出 RyR 通道表达和功能的改变。
