Leclercq-Foucart J, Forget P P, Van Cutsem J L
J Pediatr Gastroenterol Nutr. 1987 Jan-Feb;6(1):66-70. doi: 10.1097/00005176-198701000-00012.
The lactulose-rhamnose intestinal permeability test was performed in 10 cystic fibrosis (CF) children. Urine was collected for 5 h after oral intake of the test solution. A single thin-layer chromatography followed by densitometry was used for the measurement of lactulose and rhamnose concentrations in the urine specimens. The excretion of each molecule was expressed as the percentage of the orally administered dose excreted and the lactulose-rhamnose ratio was the ratio of the percentage quantities of each probe molecule excreted. The mean lactulose-rhamnose excretion ratio in CF patients and controls was 0.16 and 0.038, respectively (p less than 0.001). The mean 5-h lactulose excretion was 2% and 0.28% in CF patients and control subjects, respectively (p less than 0.001). The mean 5-h rhamnose excretion was 12.8% and 7.6% in CF patients and control subjects (p less than 0.05). We conclude that CF patients have an increased intestinal permeability to lactulose and rhamnose. Further studies are needed in order to elucidate the mechanisms involved as well as the eventual nutritional implications.
对10名囊性纤维化（CF）患儿进行了乳果糖-鼠李糖肠道通透性测试。口服测试溶液后收集5小时的尿液。采用单次薄层色谱法并结合光密度测定法来测量尿液标本中乳果糖和鼠李糖的浓度。每个分子的排泄量以口服给药剂量排泄的百分比表示，乳果糖-鼠李糖比率是每个探针分子排泄量百分比的比值。CF患者和对照组的平均乳果糖-鼠李糖排泄率分别为0.16和0.038（p<0.001）。CF患者和对照受试者的平均5小时乳果糖排泄量分别为2%和0.28%（p<0.001）。CF患者和对照受试者的平均5小时鼠李糖排泄量分别为12.8%和7.6%（p<0.05）。我们得出结论，CF患者对乳果糖和鼠李糖的肠道通透性增加。需要进一步研究以阐明其中涉及的机制以及最终的营养影响。
