克罗恩病和囊性纤维化。
Crohn's disease and cystic fibrosis.
作者信息
Lloyd-Still J D
机构信息
Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614.
出版信息
Dig Dis Sci. 1994 Apr;39(4):880-5. doi: 10.1007/BF02087437.
Advances in investigative techniques have led to increasing reports of Crohn's disease in CF patients. A retrospective review of the literature on IBD in CF showed findings characterized by ileocolitis with fistula formation; 83% required surgery. A prospective survey of 11,321 CF patients attending 49 CF centers revealed 28 with IBD (25 Crohn's, three ulcerative colitis), ages 4-20 years, mean 15.6 years. The prevalence rate of IBD (247/10(5)) was 7x controls and was accounted for by Crohn's disease (221/10(5)) which was 17x controls. The mechanisms that predispose CF patients to Crohn's disease are discussed.
调查技术的进步导致囊性纤维化（CF）患者中克罗恩病的报告日益增多。一项对CF患者中炎症性肠病（IBD）文献的回顾性研究显示，其特征为伴有瘘管形成的回结肠炎症；83%的患者需要手术治疗。一项对49个CF中心的11321例CF患者的前瞻性调查发现，有28例患有IBD（25例克罗恩病，3例溃疡性结肠炎），年龄在4至20岁之间，平均15.6岁。IBD的患病率（247/10⁵）是对照组的7倍，且主要由克罗恩病（221/10⁵）导致，其患病率是对照组的17倍。文中讨论了使CF患者易患克罗恩病的机制。
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