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儿童腹膜透析导管的外科管理:1800个患者月随访的五年经验

Surgical management of peritoneal dialysis catheters in children: five-year experience with 1,800 patient-month follow-up.

作者信息

Stone M M, Fonkalsrud E W, Salusky I B, Takiff H, Hall T, Fine R N

出版信息

J Pediatr Surg. 1986 Dec;21(12):1177-81. doi: 10.1016/0022-3468(86)90033-3.

Abstract

Currently at our institution more than 90% of the children with end-stage renal disease are managed with continuous ambulatory peritoneal dialysis (CAPD) in preference to hemodialysis until a successful transplant is accomplished. Recent refinements in CAPD catheters and dialysis techniques have greatly added to the many medical, psychological, and economic advantages of CAPD compared with chronic hemodialysis. Ninety-three patients less than 21 years of age underwent insertion of 167 peritoneal dialysis (PD) catheters over a 5-year period. A variety of PD catheters were used, including 121 (73%) double-cuff Tenckhoff catheters, 22 (13%) single-cuff, and 24 (14%) column disc catheters (Lifecaths, Physio-Control Corp, Redmond, WA). There were three (3%) noncatheter-related mortalities and minimal significant morbidity during the 1,819 patient-months of catheter use. Exit site infections (61%) and peritonitis (59%) were frequent but minor complications, occasionally requiring catheter replacement. Other noninfectious complications included abdominal hernias (42%), dialysis leaks (14%), distal cuff extrusion (11%), catheter obstruction (7%), and hydrothorax (2%). Forty-five of the 60 hernias (75%) were surgically repaired in patients while receiving CAPD. Persistent or recurrent peritonitis was common with Pseudomonas, Serratia, and fungal infections and often resulted in catheter removal and loss of the peritoneal dialysis membrane. Catheter survival for the double-cuff Tenckhoff was significantly better (P .005) than the single-cuff or Lifecath. Based on this experience we have found that using specific operative techniques for CAPD catheter placement and early surgical management for severe peritonitis reduces the incidence of complications and modality failure.

摘要

目前在我们机构,超过90%的终末期肾病患儿优先采用持续性非卧床腹膜透析(CAPD)治疗,而非血液透析,直至成功完成移植手术。与慢性血液透析相比,CAPD导管和透析技术的最新改进极大地增加了CAPD在医学、心理和经济方面的诸多优势。在5年期间,93名年龄小于21岁的患者接受了167根腹膜透析(PD)导管的置入。使用了多种PD导管,包括121根(73%)双套Tenckhoff导管、22根(13%)单套导管和24根(14%)柱状盘形导管(Lifecaths,Physio-Control公司,华盛顿州雷德蒙德)。在1819个患者导管使用月期间,有3例(3%)与导管无关的死亡病例,且严重并发症极少。出口处感染(61%)和腹膜炎(59%)很常见,但为轻微并发症,偶尔需要更换导管。其他非感染性并发症包括腹壁疝(42%)、透析液渗漏(14%)、远端套囊挤出(11%)、导管阻塞(7%)和胸腔积液(2%)。60例疝中的45例(75%)在患者接受CAPD治疗期间进行了手术修复。铜绿假单胞菌、沙雷菌和真菌感染导致的持续性或复发性腹膜炎很常见,常导致导管拔除和腹膜透析膜丧失。双套Tenckhoff导管的导管存活时间明显优于单套导管或Lifecath导管(P<0.005)。基于这一经验,我们发现采用特定的手术技术进行CAPD导管置入以及对严重腹膜炎进行早期手术管理可降低并发症发生率和治疗方式失败率。

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