Selaginellin derivatives from Selaginella tamariscina and evaluation for anti-breast cancer activity.
作者信息
Wen Jing, Sha Dong-Mei, He Xiao-Yong, Tian Yu-Han, Ni Shuai-Cong, He Bin, Liu Yuan, Yan Xin-Jia
机构信息
Institute of Qinghai-Tibetan Plateau, Southwest Minzu University, Chengdu, 610225, China; School of Pharmacy, Sichuan College of Traditional Chinese Medicine, Mianyang, 621000, China.
Institute of Qinghai-Tibetan Plateau, Southwest Minzu University, Chengdu, 610225, China.
出版信息
Phytochemistry. 2024 Jan;217:113919. doi: 10.1016/j.phytochem.2023.113919. Epub 2023 Nov 11.
A phytochemical investigation of Selaginella tamariscina led to the isolation of 17 selaginellin derivatives. Their inhibitory activities against breast cancer cells were screened, and preliminary structure-activity relationships were also established. Among them, dimeric selaginellin 17 showed potential activity against MDA-MB-231 cells with an IC value of 3.2 ± 0.1 μM, corresponding to 4-fold higher potency than the reference compound 5-FU (IC 14.8 ± 0.2 μM). Mechanistic studies indicated that 17 could cause G2/M phase arrest in MDA-MB-231 cells and induce apoptosis accompanied by increased ROS levels.
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