Medical Biophysics Division, Physics Department, Faculty of Science, Helwan University, Cairo, Egypt.
Nawah Scientific Co., Cairo, Egypt.
Sci Rep. 2023 Nov 12;13(1):19712. doi: 10.1038/s41598-023-46980-6.
Fibromyalgia (FM) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, and cognitive impairment. Despite the availability of various treatment options, FM remains a challenging condition to manage. In the present study, we investigated the efficacy of formulated nanodispersions of lutein and beta-carotene in treating FM-related symptoms induced by reserpine in female Wistar rats. Several techniques have been implemented to assess this efficacy at various levels, including biochemical, bioelectrical, and behavioral. Namely, oxidative stress markers, monoamine levels, electrocorticography, pain threshold test, and open field test were conducted on control, FM-induced, and FM-treated groups of animals. Our results provided compelling evidence for the efficacy of carotenoid nanodispersions in treating FM-related symptoms. Specifically, we found that the dual action of the nanodispersion, as both antioxidant and antidepressant, accounted for their beneficial effects in treating FM. With further investigation, nano-carotenoids and particularly nano-lutein could potentially become an effective alternative treatment for patients with FM who do not respond to current treatment options.
纤维肌痛（FM）是一种慢性疾病，其特征是广泛的肌肉骨骼疼痛、疲劳和认知障碍。尽管有各种治疗选择，但 FM 仍然是一种难以管理的疾病。在本研究中，我们研究了叶黄素和β-胡萝卜素配方纳米分散体治疗利血平诱导的雌性 Wistar 大鼠 FM 相关症状的疗效。我们采用了多种技术在不同水平上评估这种疗效，包括生化、生物电和行为。即，我们对对照组、FM 诱导组和 FM 治疗组的动物进行了氧化应激标志物、单胺水平、皮层电图、痛阈试验和旷场试验。我们的结果为类胡萝卜素纳米分散体治疗 FM 相关症状的疗效提供了有力的证据。具体而言，我们发现纳米分散体的双重作用，既是抗氧化剂又是抗抑郁剂，解释了它们在治疗 FM 中的有益作用。进一步的研究表明，纳米类胡萝卜素，特别是纳米叶黄素，可能成为对现有治疗选择无反应的 FM 患者的有效替代治疗方法。
