da Cruz Filho Iranildo José, Duarte Denise Maria Figueiredo Araújo, Marques Diego Santa Clara, da Rocha João Victor Ritinto, Diniz Emily Gabriele Marques, Brayner Fábio André, Alves Luiz Carlos, de Azevedo Albuquerque Mônica Camelo Pessoa, de Lima Aires André, Nogueira Fátima, de Lima Maria do Carmo Alves
Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, Recife, PE 50670-420 Brazil.
Global Health and Tropical Medicine, GHTM, Institute of Hygiene and Tropical Medicine, IHMT, New University of Lisbon, 1349-008 Lisbon, Portugal.
3 Biotech. 2023 Dec;13(12):391. doi: 10.1007/s13205-023-03799-2. Epub 2023 Nov 9.
Ruiz & Pav is a neotropical species found in humid forests from southern Mexico to southern Brazil. There are few studies related to the ethnopharmacological use of . Our objective was to evaluate the hydroalcoholic extract of as a potential antiparasitic agent. For this, we performed in vitro assays against strains of , , and . At the same time, immunomodulatory activity tests were carried out. The results demonstrated that the extract was able to stimulate and activate immune cells. In preliminary antiparasitic tests, structural modifications were observed in the promastigote form of and in adult worms of The extract was able to inhibit the growth of trypomastigote form of and finally showed low antiparasitic activity against strains of . It is pioneering work and these results demonstrate that extract is a promising alternative and contributes to the arsenal of possible forms of treatment to combat parasites.
The online version contains supplementary material available at 10.1007/s13205-023-03799-2.
鲁伊斯氏菌和帕氏菌是一种新热带物种，分布于从墨西哥南部到巴西南部的潮湿森林中。关于其民族药理学用途的研究很少。我们的目标是评估鲁伊斯氏菌和帕氏菌的水醇提取物作为潜在抗寄生虫剂的效果。为此，我们对克氏锥虫、枯氏锥虫、刚地弓形虫和疟原虫的菌株进行了体外试验。同时，进行了免疫调节活性测试。结果表明，该提取物能够刺激和激活免疫细胞。在初步抗寄生虫试验中，观察到前鞭毛体形式的克氏锥虫和成虫形式的枯氏锥虫的结构发生了改变。该提取物能够抑制克氏锥虫无鞭毛体形式的生长，最终对疟原虫菌株显示出较低的抗寄生虫活性。这是开创性的工作，这些结果表明鲁伊斯氏菌和帕氏菌提取物是一种有前途的替代品，为对抗寄生虫的可能治疗形式的武器库做出了贡献。
在线版本包含可在10.1007/s13205-023-03799-2获取的补充材料。
