Fang Changquan, Xu Limin
Department of Pulmonary and Critical Care Medicine, Huizhou Central People's Hospital, Huizhou, Guangdong Province, Peoples' Republic of China.
Department of Geriatrics, Huizhou First People's Hospital, Huizhou, Guangdong Province, People's Republic of China.
Infect Drug Resist. 2023 Nov 6;16:7063-7069. doi: 10.2147/IDR.S435246. eCollection 2023.
pneumonia frequently leads to various extrapulmonary complications; however, reports of -pneumonia complicated by pulmonary thrombosis are uncommon. We report a case of severe pneumonia in a patient with a history of poultry contact and clinical manifestations including hyperpyrexia, dyspnea, and respiratory failure, which necessitated tracheal intubation for assisted ventilation. in bronchoalveolar lavage fluid was detected with metagenomic next-generation sequencing. Following targeted antibiotic therapy, the fever subsided, although dyspnea persisted without significant improvement, and chest pain developed. Compared to previous measurements, the D-dimer level increased, and CT pulmonary angiography revealed thromboses in the pulmonary artery trunk and left pulmonary artery. The symptoms improved after anticoagulant treatment, and the patient was discharged subsequently. This study suggests that infection may be associated with the formation of pulmonary thrombosis. Additional clinical data are required to support this inference. Following targeted antibiotic therapy, if persistent dyspnea, chest pain, and increased D-dimer level are present, pulmonary thrombosis should be considered, and pulmonary artery angiography can confirm the diagnosis.
肺炎常导致各种肺外并发症;然而,关于肺炎并发肺血栓形成的报道并不常见。我们报告一例有家禽接触史的严重肺炎患者,临床表现包括高热、呼吸困难和呼吸衰竭,需气管插管进行辅助通气。通过宏基因组下一代测序在支气管肺泡灌洗液中检测到(某种病原体)。经过针对性抗生素治疗后,发热消退,尽管呼吸困难持续且无明显改善,并出现胸痛。与之前测量结果相比,D - 二聚体水平升高,胸部CT血管造影显示肺动脉主干和左肺动脉有血栓形成。抗凝治疗后症状改善,患者随后出院。本研究提示(某种病原体)感染可能与肺血栓形成有关。需要更多临床数据来支持这一推断。经过针对性抗生素治疗后,如果出现持续呼吸困难、胸痛和D - 二聚体水平升高,应考虑肺血栓形成,肺动脉造影可确诊。