Li Mengjie, Wang Biao, Liu Peng, Wang Huan, Zhu Jian
Department of Respiratory and Critical Care Medicine, Cangzhou Fifth Hospital (People's Hospital of Qingxian), Cangzhou 062650, China.
Department of Thoracic Cardiovascular Surgery, General Hospital of Central Theater Command of The People's Liberation Army, No. 627 Wuluo Road, Wuchang District, Wuhan 430070, China.
Open Life Sci. 2023 Apr 12;18(1):20220596. doi: 10.1515/biol-2022-0596. eCollection 2023.
() pneumonia is a zoonotic infectious disease caused by , which is often underdiagnosed. The application of metagenomic next-generation sequencing (mNGS) provides an unbiased method for the detection of unknown pathogens. A 46-year-old man received empirical treatment with piperacillin-tazobactam and moxifloxacin after an initial diagnosis of prostatitis and pneumonia. However, he experienced recurrent symptoms and a cough, and a chest computed tomography (CT) showed aggravated pulmonary inflammation. Upon further questioning, the patient recalled a history of contact with pigeons, and a bronchoscope alveolar lavage fluid analysis with mNGS suggested infection. Following treatment with doxycycline, the patient's symptoms were rapidly alleviated, and chest CT showed pulmonary lesions absorption. The patient was followed up for 1 month without any discomfort. This case highlights that initial manifestations of pneumonia may present with atypical symptoms such as prostatitis. Furthermore, mNGS can be a useful tool for the detection of rare or unknown pathogens such as .
（）肺炎是一种由……引起的人畜共患传染病，常被漏诊。宏基因组下一代测序（mNGS）的应用为检测未知病原体提供了一种无偏差的方法。一名46岁男性最初被诊断为前列腺炎和肺炎后，接受了哌拉西林-他唑巴坦和莫西沙星的经验性治疗。然而，他出现了症状反复和咳嗽，胸部计算机断层扫描（CT）显示肺部炎症加重。进一步询问后，患者回忆起有接触鸽子的病史，mNGS对支气管镜肺泡灌洗液的分析提示……感染。使用强力霉素治疗后，患者症状迅速缓解，胸部CT显示肺部病变吸收。对患者进行了1个月的随访，无任何不适。该病例突出表明，……肺炎的初始表现可能呈现非典型症状，如前列腺炎。此外，mNGS可成为检测罕见或未知病原体（如……）的有用工具。
