• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

分泌卷曲相关蛋白 2 是预测人类胰腺癌患者生存的指标，与纤维化有关。

Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis.

机构信息

Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.

Department of Cellular and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.

出版信息

Cancer Biomark. 2023;38(3):287-300. doi: 10.3233/CBM-220044.

DOI:10.3233/CBM-220044
PMID:37955079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10977449/
Abstract

Pancreatic adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year survival rates of 9%. We hypothesized that secreted frizzled-related protein 2 (SFRP2) may influence stromal growth in pancreatic cancer, since it increases fibrosis and collagen production in non-neoplastic pathologies. We assessed SFRP2 value as a biomarker and assessed its function in PDAC. SFRP2 gene expression in patients with PDAC was analyzed using TCGA data. Disease free survival (DFS) was analyzed using Kaplan Meier test. The effect of KRAS inhibition on SFRP2 expression in PDAC cells was assessed. The associations of stromal content with SFPR2 mRNA and protein with fibrosis were analyzed. The role of SFRP2 in mesenchymal transformation was assessed by western blot in fibroblasts. Of all cancers in TCGA, SFRP2 levels were highest in PDAC, and higher in PDAC than normal tissues (n= 234, p= 0.0003). High SFRP2 levels correlated with decreased DFS (p= 0.0097). KRAS inhibition reduced SFRP2 levels. Spearman correlation was 0.81 between stromal RNA and SFRP2 in human PDAC, and 0.75 between fibrosis and SFRP2 levels in PDAC tumors. SFRP2-treated fibroblasts displayed mesenchymal characteristics. SFRP2 is prognostic for PDAC survival, regulated by KRAS, and associated with PDAC fibrosis.

摘要

胰腺导管腺癌 (PDAC) 是最致命的癌症之一，五年生存率为 9%。我们假设分泌卷曲相关蛋白 2 (SFRP2) 可能会影响胰腺癌中的基质生长，因为它会增加非肿瘤性病变中的纤维化和胶原生成。我们评估了 SFRP2 作为生物标志物的价值，并评估了其在 PDAC 中的功能。使用 TCGA 数据分析 PDAC 患者的 SFRP2 基因表达。使用 Kaplan-Meier 检验分析无病生存期 (DFS)。评估 KRAS 抑制对 PDAC 细胞中 SFRP2 表达的影响。分析基质含量与 SFPR2 mRNA 和蛋白与纤维化的相关性。通过 Western blot 在成纤维细胞中评估 SFRP2 在间质转化中的作用。在 TCGA 中的所有癌症中，SFRP2 水平在 PDAC 中最高，并且在 PDAC 中高于正常组织 (n=234，p=0.0003)。高 SFRP2 水平与 DFS 降低相关 (p=0.0097)。KRAS 抑制降低了 SFRP2 水平。在人类 PDAC 中，基质 RNA 与 SFRP2 之间的 Spearman 相关系数为 0.81，PDAC 肿瘤中纤维化与 SFRP2 水平之间的相关系数为 0.75。SFRP2 处理的成纤维细胞显示出间充质特征。SFRP2 是 PDAC 生存的预后指标，受 KRAS 调节，并与 PDAC 纤维化相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/84081b31b86b/cbm-38-cbm220044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/a0f9ffeafa3a/cbm-38-cbm220044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/cb04e745c19e/cbm-38-cbm220044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/c74632ba252c/cbm-38-cbm220044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/e84be93f3deb/cbm-38-cbm220044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/7a9ac844bcbd/cbm-38-cbm220044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/84081b31b86b/cbm-38-cbm220044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/a0f9ffeafa3a/cbm-38-cbm220044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/cb04e745c19e/cbm-38-cbm220044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/c74632ba252c/cbm-38-cbm220044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/e84be93f3deb/cbm-38-cbm220044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/7a9ac844bcbd/cbm-38-cbm220044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bbb/10977449/84081b31b86b/cbm-38-cbm220044-g006.jpg

相似文献

1
Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis.分泌卷曲相关蛋白 2 是预测人类胰腺癌患者生存的指标，与纤维化有关。
Cancer Biomark. 2023;38(3):287-300. doi: 10.3233/CBM-220044.
2
Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer.极光激酶 A 及其激活剂 TPX2 是 KRAS 诱导的胰腺癌的潜在治疗靶点。
Cell Oncol (Dordr). 2020 Jun;43(3):445-460. doi: 10.1007/s13402-020-00498-5. Epub 2020 Mar 19.
3
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.抑制 Cxcr2 破坏肿瘤-基质相互作用，并改善胰腺导管腺癌小鼠模型的生存。
J Clin Invest. 2011 Oct;121(10):4106-17. doi: 10.1172/JCI42754. Epub 2011 Sep 19.
4
Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.碳酸酐酶 9 通过调节 pH 值介导激活 KRAS 的胰腺癌细胞对低氧的存活反应。
Gastroenterology. 2019 Sep;157(3):823-837. doi: 10.1053/j.gastro.2019.05.004. Epub 2019 May 9.
5
MiR-143-3p suppresses tumorigenesis in pancreatic ductal adenocarcinoma by targeting KRAS.miR-143-3p 通过靶向 KRAS 抑制胰腺导管腺癌的肿瘤发生。
Biomed Pharmacother. 2019 Nov;119:109424. doi: 10.1016/j.biopha.2019.109424. Epub 2019 Sep 12.
6
Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.KRAS 突变、持久性有机污染物和微量元素对胰腺导管腺癌生存的影响。
Environ Res. 2020 Nov;190:109781. doi: 10.1016/j.envres.2020.109781. Epub 2020 Jun 11.
7
Mutant Circulating Tumor DNA Is an Accurate Tool for Pancreatic Cancer Monitoring.循环肿瘤 DNA 突变是一种用于胰腺癌监测的精确工具。
Oncologist. 2018 May;23(5):566-572. doi: 10.1634/theoncologist.2017-0467. Epub 2018 Jan 25.
8
G12D Mutation Subtype in Pancreatic Ductal Adenocarcinoma: Does It Influence Prognosis or Stage of Disease at Presentation?胰腺导管腺癌中的 G12D 突变亚型：它是否影响预后或疾病的分期？
Cells. 2022 Oct 10;11(19):3175. doi: 10.3390/cells11193175.
9
Concentrations of trace elements and KRAS mutations in pancreatic ductal adenocarcinoma.胰腺导管腺癌中的微量元素浓度和 KRAS 突变。
Environ Mol Mutagen. 2019 Oct;60(8):693-703. doi: 10.1002/em.22296. Epub 2019 May 23.
10
Novel stromal biomarker screening in pancreatic cancer patients using the in vitro cancer-stromal interaction model.利用体外癌-基质相互作用模型对胰腺癌患者进行新型基质生物标志物筛选。
BMC Gastroenterol. 2020 Dec 9;20(1):411. doi: 10.1186/s12876-020-01556-w.

本文引用的文献

1
Adult skin fibroblast state change in murine wound healing.在鼠类伤口愈合中，成人皮肤成纤维细胞的状态变化。
Sci Rep. 2023 Jan 17;13(1):886. doi: 10.1038/s41598-022-27152-4.
2
Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.鉴定无核苷酸状态为抑制特定致癌性 RAS 突变体的治疗弱点。
Cell Rep. 2022 Feb 8;38(6):110322. doi: 10.1016/j.celrep.2022.110322.
3
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS Inhibitor.鉴定 MRTX1133，一种非共价、有效和选择性的 KRAS 抑制剂。
J Med Chem. 2022 Feb 24;65(4):3123-3133. doi: 10.1021/acs.jmedchem.1c01688. Epub 2021 Dec 10.
4
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma.用针对分泌型卷曲相关蛋白2的单克隆抗体克服转移性骨肉瘤中的PD-1抑制剂耐药性。
Cancers (Basel). 2021 May 30;13(11):2696. doi: 10.3390/cancers13112696.
5
Stroma-targeting strategies in pancreatic cancer: Past lessons, challenges and prospects.胰腺癌中的基质靶向策略：过去的经验教训、挑战与展望。
World J Gastroenterol. 2021 May 14;27(18):2105-2121. doi: 10.3748/wjg.v27.i18.2105.
6
SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma.SFRP2 通过抑制 SOX2 诱导脑胶质瘤中的间质亚型转换。
Oncogene. 2021 Aug;40(32):5066-5080. doi: 10.1038/s41388-021-01825-2. Epub 2021 May 21.
7
Cancer Statistics, 2021.癌症统计数据，2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.
8
sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients.sFRP2 取代 VEGF 成为黑色素瘤中与年龄相关的血管生成驱动因素，影响老年患者对抗 VEGF 治疗的反应。
Clin Cancer Res. 2020 Nov 1;26(21):5709-5719. doi: 10.1158/1078-0432.CCR-20-0446.
9
Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination.与肺上皮细胞的串扰调节 Sfrp2 介导的乳腺癌传播潜伏期。
Nat Cell Biol. 2020 Mar;22(3):289-296. doi: 10.1038/s41556-020-0474-3. Epub 2020 Feb 24.
10
Pancreatic Stellate Cells: The Key Orchestrator of The Pancreatic Tumor Microenvironment.胰腺星状细胞：胰腺肿瘤微环境的关键协调者。
Adv Exp Med Biol. 2020;1234:57-70. doi: 10.1007/978-3-030-37184-5_5.