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[甲氨蝶呤治疗输卵管异位妊娠:它是一种有效的治疗方法吗?]

[Management of tubal ectopic pregnancies with methotrexate : is it an effective treatment ?].

作者信息

Dujardin Maurine, Timmermans Marie, Closon François, De Landsheere Laurent, Nisolle Michelle

机构信息

Étudiante en Master 3 Médecine, ULiège, Belgique.

Service de Gynécologie-Obstétrique, CHU Citadelle, Liège, Belgique.

出版信息

Rev Med Liege. 2023 Nov;78(11):634-640.

Abstract

Ectopic pregnancy is a gynecological emergency. The hCG level, the clinical presentation and the ultrasound remain the key steps for the diagnosis. The criteria tend to be more and more codified to decide on the optimal treatment, however, there is no consensus. The aim of this study was to evaluate the impact of applying a mathematical formula to predict the failure rate of metho-trexate for tubal ectopic pregnancy. A retrospective, monocentric study was conducted on a cohort of 193 patients for whom the formula could be calculated. Regarding our professional practice, the success rate of first-line metho-trexate is 93 %. It would increase to 96 % if the formula had been applied. The use of the formula would also reduce the rate of first-line surgery by 12 %.

摘要

异位妊娠是一种妇科急症。人绒毛膜促性腺激素(hCG)水平、临床表现及超声检查仍是诊断的关键步骤。在决定最佳治疗方案方面,相关标准正日益规范化,然而,目前尚无共识。本研究的目的是评估应用数学公式预测甲氨蝶呤治疗输卵管异位妊娠失败率的影响。对193例可计算该公式的患者进行了一项回顾性单中心研究。就我们的专业实践而言,一线甲氨蝶呤的成功率为93%。如果应用该公式,成功率将增至96%。应用该公式还可使一线手术率降低12%。

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