Uppsala University Children's Hospital, Uppsala, Sweden.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Acta Paediatr. 2024 Feb;113(2):286-295. doi: 10.1111/apa.17030. Epub 2023 Nov 13.
To investigate the prevalence and possible risk factors for the development of impaired glucose metabolism in children and adolescents with obesity.
This was a cross-sectional retrospective cohort study, including 634 patients with obesity and 98 normal weight controls aged 4-18 years from the Beta-cell function in Juvenile Diabetes and Obesity (Beta-JUDO) cohort, a dual-centre study at Uppsala University Hospital (Sweden) and Paracelsus Medical University Hospital (Salzburg, Austria) conducted between 2012 and 2021. A longitudinal subgroup analysis, including 188 of these subjects was performed. Impaired glucose metabolism was diagnosed by oral glucose tolerance tests according to American Diabetes Association criteria.
The prevalence of impaired glucose metabolism was 72% in Uppsala patients, 24% in Salzburg patients, 30% in Uppsala controls and 13% in Salzburg controls. The prevalence was lower at the follow-up visits compared with baseline both in Uppsala and Salzburg patients. A family history of type 2 diabetes showed the strongest association with impaired glucose metabolism at the follow-up visits besides belonging to the Uppsala cohort.
The prevalence of impaired glucose metabolism was extraordinarily high in Swedish children and adolescents with obesity, but decreased during the follow-up period.
调查肥胖儿童和青少年中葡萄糖代谢受损的流行情况及其可能的危险因素。
这是一项横断面回顾性队列研究，纳入了来自 Beta-cell function in Juvenile Diabetes and Obesity (Beta-JUDO) 队列的 634 名肥胖患者和 98 名正常体重对照者，该队列研究于 2012 年至 2021 年在瑞典乌普萨拉大学医院和奥地利萨尔茨堡帕拉塞尔苏斯医科大学医院进行，为一项双中心研究。对其中 188 名受试者进行了纵向亚组分析。葡萄糖代谢受损根据美国糖尿病协会标准通过口服葡萄糖耐量试验进行诊断。
乌普萨拉患者的葡萄糖代谢受损患病率为 72%，萨尔茨堡患者为 24%，乌普萨拉对照组为 30%，萨尔茨堡对照组为 13%。与基线相比，乌普萨拉和萨尔茨堡患者在随访时的患病率均较低。除了属于乌普萨拉队列外，2 型糖尿病家族史是随访时葡萄糖代谢受损的最强关联因素。
瑞典肥胖儿童和青少年的葡萄糖代谢受损患病率极高，但在随访期间有所下降。
