Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy.
Department of Medical Imaging, Azienda Ospedaliera Universitaria di Cagliari, S.S: 554, Km 4,500 - CAP, Monserrato, 09042, Cagliari, Italy.
Brain Imaging Behav. 2024 Feb;18(1):141-158. doi: 10.1007/s11682-023-00814-1. Epub 2023 Nov 13.
To examine the corpus callosum's (CC) integrity in terms of fractional anisotropy (FA) and how it affects resting-state hemispheric connectivity (rs-IHC) and cognitive function in healthy individuals. Sixty-eight healthy individuals were recruited for the study. The global FA (gFA) and FA values of each CC tract (forceps minor, body, tapetum, and forceps major) were evaluated using diffusion-weighted imaging (DWI) sequences. The homotopic functional connectivity technique was used to quantify the effects of FA in the CC tracts on bilateral functional connectivity, including the confounding effect of gFA. Brain regions with higher or lower rs-IHC were identified using the threshold-free cluster enhancement family-wise error-corrected p-value of 0.05. The null hypothesis was rejected if the p-value was ≤ 0.05 for the nonparametric partial correlation technique. Several clusters of increased rs-IHC were identified in relation to the FA of individual CC tracts, each with a unique topographic distribution and extension. Only forceps minor FA values correlated with cognitive scores. The integrity of CC influences rs-IHC differently in healthy subjects. Specifically, forceps minor anisotropy impacts rs-IHC and cognition more than other CC tracts do.
为了研究胼胝体（CC）各向异性分数（FA）的完整性及其对健康个体静息状态半球间连通性（rs-IHC）和认知功能的影响。本研究招募了 68 名健康个体。采用弥散加权成像（DWI）序列评估全脑 FA（gFA）和各 CC 束（小钳、体部、放射冠和大钳）的 FA 值。采用同型功能连接技术来量化 CC 束 FA 对双侧功能连接的影响，包括 gFA 的混杂效应。采用阈值自由聚类增强方法，校正了脑区 rs-IHC 差异的组间错误发现率（family-wise error，FWE）p 值为 0.05。如果非参数偏相关技术的 p 值≤0.05，则拒绝零假设。与个体 CC 束 FA 相关的 rs-IHC 增加的几个簇被识别，每个簇都有独特的拓扑分布和延伸。只有小钳 FA 值与认知评分相关。CC 的完整性在健康受试者中对 rs-IHC 的影响不同。具体来说，小钳的各向异性对 rs-IHC 和认知的影响大于其他 CC 束。
