Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China.
PLoS One. 2012;7(9):e45476. doi: 10.1371/journal.pone.0045476. Epub 2012 Sep 24.
Diffusion tensor imaging (DTI) study revealed reduced fractional anisotropy (FA) values in the corpus callosum (CC) in migraine patients without aura. Abnormalities in white matter integrity, particularly in the CC, may affect inter-hemispheric resting state functional connectivity (RSFC). Unfortunately, relatively little is known about the alterations in functional interactions between the cerebral hemispheres during resting state in migraine patients without aura, and even less about how the inter-hemispheric RSFC are affected by the abnormalities of the CC.
Twenty-one migraine patients without aura and 21 healthy controls participated in this study, age-, sex-, and education-matched. Tract-based spatial statistics (TBSS) was employed to investigate the white matter alterations of the CC. Meanwhile, voxel-mirrored homotopic connectivity (VMHC) was used to compare the inter-hemispheric RSFC differences between the patients and controls. TBSS analysis revealed reduced FA values in the genu and the splenium of CC in patient group. VMHC analysis showed decreased inter-hemispheric RSFC of anterior cingulate cortex (ACC) in migraine patients without aura relative to that of the controls. Furthermore, in migraine patients without aura, the reduced FA values of the genu of CC correlated with the decreased inter-hemispheric RSFC of the ACC.
Our findings demonstrated that the migraine patients without aura showed reduced FA values of the genu of CC and decreased inter-hemispheric RSFC of the ACC. The correlation between the above structural and functional changes suggested that the reduced fractional anisotropy (FA) of CC modulates inter-hemispheric VMHC in migraine patients without aura. Our results demonstrated that the VMHC alterations of ACC can reflect the FA changes of the genu of CC in migraine patients without aura.
弥散张量成像（DTI）研究显示，无先兆偏头痛患者胼胝体（CC）的各向异性分数（FA）值降低。白质完整性异常，特别是 CC，可能会影响大脑两半球之间的静息状态功能连接（RSFC）。不幸的是，对于无先兆偏头痛患者静息状态时大脑两半球之间功能相互作用的改变，我们知之甚少，甚至更少了解 CC 的异常如何影响大脑两半球之间的 RSFC。
本研究纳入了 21 名无先兆偏头痛患者和 21 名健康对照者，年龄、性别和教育程度相匹配。采用基于束的空间统计学（TBSS）分析 CC 的白质改变。同时，采用体素镜像同伦相关（VMHC）比较患者组和对照组之间大脑两半球之间 RSFC 的差异。TBSS 分析显示，患者组 CC 的体部和压部 FA 值降低。VMHC 分析显示，无先兆偏头痛患者大脑两半球之间的 RSFC 中前扣带回皮质（ACC）的降低。此外，无先兆偏头痛患者 CC 的体部 FA 值降低与 ACC 的大脑两半球之间 RSFC 的降低相关。
我们的研究结果表明，无先兆偏头痛患者 CC 的体部 FA 值降低，ACC 的大脑两半球之间 RSFC 降低。上述结构和功能变化之间的相关性表明，CC 的 FA 值降低调节了无先兆偏头痛患者的大脑两半球之间的 VMHC。我们的结果表明，ACC 的 VMHC 改变可以反映无先兆偏头痛患者 CC 体部的 FA 变化。
