Takeda Y, Takano Y, Kamiya H
Jpn J Pharmacol. 1986 Sep;42(1):145-9. doi: 10.1254/jjp.42.145.
Intraperitoneal injection of cholecystokinin octapeptide (10 and 100 micrograms/kg, i.p.), but not the tetra-peptide (1 mg/kg, i.p.), into mice significantly reduced spontaneous locomotor activity in a dose-dependent manner. The increase in locomotor activity induced by methamphetamine (1 mg/kg, i.p.) and thyrotropin-releasing hormone (5 mg/kg, i.p.) was significantly reduced by cholecystokinin peptides. However, the inhibitory effects of these peptides differed. Neither the tetra nor octa peptide influenced the increased locomotor activity induced by nomifensine (5 mg/kg, i.p.), apomorphine (3 mg/kg, i.p.) or scopolamine (2 mg/kg, i.p.). Thus, these cholecystokinin peptides seem to selectively antagonize increased locomotor activity via the presynaptic dopaminergic system.
向小鼠腹腔注射八肽胆囊收缩素（10和100微克/千克，腹腔注射），而非四肽（1毫克/千克，腹腔注射），可显著降低自发运动活性，且呈剂量依赖性。八肽胆囊收缩素可显著降低由甲基苯丙胺（1毫克/千克，腹腔注射）和促甲状腺激素释放激素（5毫克/千克，腹腔注射）诱导的运动活性增加。然而，这些肽的抑制作用有所不同。四肽和八肽均不影响由诺米芬辛（5毫克/千克，腹腔注射）、阿扑吗啡（3毫克/千克，腹腔注射）或东莨菪碱（2毫克/千克，腹腔注射）诱导的运动活性增加。因此，这些胆囊收缩素肽似乎通过突触前多巴胺能系统选择性拮抗运动活性增加。
