Hsiao S, Katsuura G, Itoh S
Behav Neurosci. 1985 Oct;99(5):853-60. doi: 10.1037//0735-7044.99.5.853.
Production of lesions in the brain dopamine (DA) system by intraventricular injection of 6-hydroxydopamine (6-OHDA) resulted in increased responses to apomorphine (0.5 mg/kg, sc) and reduced responses to methamphetamine (0.15 mg/kg, sc). It also made animals increase responding to cholecystokinin octapeptide (CCK-8; 0.5-2 micrograms, intracerebroventricularly [icv]) and reduce responding to cholecystokinin tetrapeptide (CCK-4; 0.5-2 micrograms, icv). Response changes were quantified by measuring the level of general activity. The result indicates that DA dysfunction can affect not only DA receptor sensitivity but also the sensitivity of the CCK system. The response to CCK-8 was partially blocked by a selective CCK-8 antagonist, proglumide (5 micrograms, icv), a result suggesting the involvement of the CCK-8 receptor system. Thus, manipulation of one neuronal system could induce sensitivity changes in another closely related system.
脑室内注射6-羟基多巴胺（6-OHDA）致使脑多巴胺（DA）系统产生损伤，这导致对阿扑吗啡（0.5毫克/千克，皮下注射）的反应增强，而对甲基苯丙胺（0.15毫克/千克，皮下注射）的反应减弱。它还使动物对胆囊收缩素八肽（CCK-8；0.5 - 2微克，脑室内注射[icv]）的反应增加，对胆囊收缩素四肽（CCK-4；0.5 - 2微克，icv）的反应减少。通过测量总体活动水平对反应变化进行量化。结果表明，DA功能障碍不仅会影响DA受体敏感性，还会影响CCK系统的敏感性。对CCK-8的反应被一种选择性CCK-8拮抗剂丙谷胺（5微克，icv）部分阻断，这一结果提示CCK-8受体系统参与其中。因此，对一个神经元系统的操控可诱导另一个密切相关系统的敏感性变化。
