表观遗传衰老与 CARDIA 研究中中年肌肉量和衰减的测量值相关。

Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study.

机构信息

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Center for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 2024 Mar 1;79(3). doi: 10.1093/gerona/glad261.

DOI:10.1093/gerona/glad261

PMID:37956337

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10876078/

Abstract

BACKGROUND

GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown.

METHODS

We estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000-2001) and 20 (2005-2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010-2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements.

RESULTS

In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average -0.089 Hounsfield unit (HU; 95% CI: -0.146, -0.032) lower lean muscle attenuation and an average -0.049 HU (95% CI: -0.092, -0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only.

CONCLUSIONS

Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.

摘要

背景

GrimAge 加速（GAA）是一种代表生理衰老的表观遗传标志物，与癌症和心血管疾病等与年龄相关的疾病有关。然而，GAA 与肌肉质量和功能之间的关系尚不清楚。

方法

我们在冠状动脉风险发展在年轻人（CARDIA）研究中的 1118 名黑人和白人参与者中估计了 GAA 的指标，这些参与者在研究期间（Y）15 岁（2000-2001 年）和 20 岁（2005-2006 年）进行了检查。在 Y25 访视（2010-2011 年）时使用 CT 扫描测量腹部肌肉成分。我们使用多元回归模型来检查 GAA 估计值与肌肉成像测量值之间的关联。

结果

在 CARDIA 研究中，GAA 每增加 1 年，腹部肌肉的肌间脂肪组织（IMAT）体积平均增加 1.1%（95%置信区间：0.6%，1.5%）。GAA 每增加 1 年，腹部肌肉的瘦肌肉衰减平均降低 0.089 亨氏单位（HU；95%置信区间：-0.146，-0.032），IMAT 衰减平均降低 0.049 HU（95%置信区间：-0.092，-0.007）。分层分析显示，GAA 与女性腹部肌肉 IMAT 体积增加的相关性更强，与白种人瘦肌肉衰减的相关性显著。