Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Arch Gerontol Geriatr. 2024 Feb;117:105251. doi: 10.1016/j.archger.2023.105251. Epub 2023 Oct 24.
This study aimed to validate the proposed Korean Working Group on Sarcopenia (KWGS) guideline, which introduces the concept of functional sarcopenia, in older Korean adults.
Data from the Aging Study of Pyeongchang Rural Area, a longitudinal cohort of community-dwelling older adults, were utilized to compare frailty status and institutionalization-free survival among participants according to sarcopenia status. Based on the KWGS guideline, severe sarcopenia was defined as low muscle mass and strength with slow gait speed; sarcopenia (not severe) was defined as low muscle mass with low muscle strength or slow gait speed; and functional sarcopenia was defined as low muscle strength and slow gait speed without low muscle mass.
Among the 1302 participants, 329 (25.3 %) had severe sarcopenia, 147 (11.3 %) had sarcopenia (not severe), and 277 (21.3 %) had functional sarcopenia. Frailty was significantly greater in participants with any phenotype of sarcopenia than in those without sarcopenia. Additionally, participants with functional sarcopenia were frailer than those with sarcopenia (not severe). Furthermore, the rates of institutionalization and mortality were higher in participants with any phenotype of sarcopenia than in those without sarcopenia. There was no statistical difference between the rates of sarcopenia (not severe) and those with functional sarcopenia. These findings remained consistent after adjusting for age and sex.
Each phenotype according to the KWGS guideline was associated with significantly greater frailty and increased risk of institutionalization and mortality. Functional sarcopenia was associated with greater frailty and had comparable prognosis with sarcopenia (not severe).
本研究旨在验证引入功能性肌肉减少症概念的韩国肌肉减少症工作组（KWGS）指南，该指南适用于韩国老年人。
利用平昌农村地区老龄化研究的数据，该研究是一个社区居住的老年人的纵向队列，根据肌肉减少症的状态，比较参与者的虚弱状态和无机构化生存。根据 KWGS 指南，严重肌肉减少症定义为低肌肉量和力量伴慢步速；肌肉减少症（不严重）定义为低肌肉量伴低肌肉力量或慢步速；功能性肌肉减少症定义为低肌肉力量和慢步速而无低肌肉量。
在 1302 名参与者中，329 名（25.3%）有严重肌肉减少症，147 名（11.3%）有肌肉减少症（不严重），277 名（21.3%）有功能性肌肉减少症。与无肌肉减少症的参与者相比，任何肌肉减少症表型的参与者的虚弱程度显著更高。此外，有功能性肌肉减少症的参与者比有肌肉减少症（不严重）的参与者更虚弱。此外，有任何肌肉减少症表型的参与者的住院率和死亡率均高于无肌肉减少症的参与者。肌肉减少症（不严重）和有功能性肌肉减少症的参与者的发生率之间没有统计学差异。在调整年龄和性别后，这些发现仍然一致。
根据 KWGS 指南的每种表型与显著更高的虚弱程度以及更高的住院和死亡风险相关。功能性肌肉减少症与更高的虚弱程度相关，且与肌肉减少症（不严重）具有可比的预后。
