Chen Ping, Zhang Xin-Huang, Wang Ying, Lin Xian-Zhong, Kang De-Zhi, Lin Qing-Song
Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Rd, Taijiang District, Fuzhou, 350005, Fujian, China.
Chin Neurosurg J. 2023 Nov 13;9(1):31. doi: 10.1186/s41016-023-00343-2.
Acute normovolemic hemodilution (ANH) was first introduced in glioblastoma surgery, and its role in reducing allogeneic blood transfusion was investigated in this study.
This study enrolled supratentorial glioblastoma patients who received total resection. In the ANH group, the patients were required to draw blood before the operation, and the blood will be transfused back to the patient during the operation. The association between ANH and clinical features was investigated.
Sixty supratentorial glioblastoma patients were enrolled in this study, 25 patients were allocated in the ANH group, and another 35 patients were included in the control group. ANH dramatically reduced the need for allogeneic blood transfusion (3 [12%] vs 12 [34.3%], P = 0.049), and the blood transfusion per total of patients was dramatically decreased by the application of ANH (0.40 ± 1.15 units vs 1.06 ± 1.59 units, P = 0.069). Furthermore, ANH also markedly reduced the requirement of fresh frozen plasma (FFP) transfusion (2 [8%] vs 11 [31.4%], P = 0.030) and the volume of FFP transfusion per total of patients (32.00 ± 114.46 mL vs 115.71 ± 181.00 mL, P = 0.033). The complication rate was similar between the two groups.
ANH was a safe and effective blood conservation technique in glioblastoma surgery.
急性等容血液稀释（ANH）首次应用于胶质母细胞瘤手术，本研究对其在减少异体输血方面的作用进行了调查。
本研究纳入接受全切除的幕上胶质母细胞瘤患者。在ANH组中，患者需在手术前抽血，并在手术期间将血液回输给患者。研究了ANH与临床特征之间的关联。
本研究共纳入60例幕上胶质母细胞瘤患者，25例患者被分配到ANH组，另外35例患者纳入对照组。ANH显著降低了异体输血的需求（3例[12%]对12例[34.3%]，P = 0.049），并且应用ANH后每位患者的输血总量显著减少（0.40±1.15单位对1.06±1.59单位，P = 0.069）。此外，ANH还显著降低了新鲜冰冻血浆（FFP）输血的需求（2例[8%]对11例[31.4%]，P = 0.030）以及每位患者的FFP输血量（32.00±114.46 mL对115.71±181.00 mL，P = 0.033）。两组之间的并发症发生率相似。
ANH是胶质母细胞瘤手术中一种安全有效的血液保护技术。
