Xavier Rafael Gariglio Clark, Santana Clarissa Helena, de Castro Yasmin Gonçalves, de Souza Thayanne Gabryelle Viana, do Amarante Victor Santos, Santos Renato Lima, Silva Rodrigo Otávio Silveira
Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue 6627, Belo Horizonte 31270-090, Brazil.
Animals (Basel). 2023 Oct 25;13(21):3310. doi: 10.3390/ani13213310.
Pyometra, characterized by the accumulation of purulent exudate in the uterus, is the most prevalent reproductive disease in canines. While the disease often begins with mild local symptoms, it can escalate into peritonitis, sepsis, and multi-organ dysfunction, thereby posing a significant threat to life. Despite the high incidence and recognized significance of canine pyometra, gaps persist in our understanding of its epidemiology, etiology, and pathogenesis. Recent studies have, however, broadened our comprehension of this disease, shedding light on potential new infection sources, etiologies, and the application of clinical predictive biomarkers and new therapeutic protocols. This study aimed to review the current understanding of canine pyometra, with particular emphasis on the latest research concerning its etiology and epidemiology. Furthermore, it addressed key research questions and proposed directions for future investigations into various facets of canine pyometra.
子宫蓄脓症，其特征是子宫内积聚脓性渗出物，是犬类中最常见的生殖系统疾病。虽然该病通常始于轻微的局部症状，但可能会发展为腹膜炎、败血症和多器官功能障碍，从而对生命构成重大威胁。尽管犬类子宫蓄脓症发病率高且具有公认的重要性，但我们对其流行病学、病因和发病机制的理解仍存在差距。然而，最近的研究拓宽了我们对这种疾病的认识，揭示了潜在的新感染源、病因以及临床预测生物标志物和新治疗方案的应用。本研究旨在综述目前对犬类子宫蓄脓症的认识，特别强调有关其病因和流行病学的最新研究。此外，它还解决了关键研究问题，并为未来对犬类子宫蓄脓症各个方面的调查提出了方向。
