Santana Clarissa Helena, Souza Monique Ferreira, da Silva Laice Alves, de Souza Lucas Dos Reis, Santana André Marcos, Oliveira Ayisa Rodrigues, da Paixão Tatiane Alves, Santos Renato Lima
Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Departamento de Medicina Veterinária, Campus Regional de Umuarama, Universidade Estadual de Maringá, Umuarama 87506-370, PR, Brazil.
Vet Sci. 2024 Dec 26;12(1):1. doi: 10.3390/vetsci12010001.
Pseudoplacentational endometrial hyperplasia (PEH) and cystic endometrial hyperplasia (CEH) are both hyperplastic conditions that may occur in the canine uterus during diestrus. CEH can impair fertility, and, although the consequences of PEH are poorly known, this condition is significantly associated with pyometra. The aim of this study was to investigate frequencies of both PEH and CEH in female dogs according to age, size, breed, and breed group. Uteri from 300 female dogs were sampled and processed for histopathologic analyses. Lesions were identified, and frequencies were statistically compared. PEH was significantly more frequent in dogs between 4 and 12 years of age and significantly less frequent in Yorkshires than Shih-tzus, as well as in the breed group that includes Brazilian Terriers and Yorkshires. CEH was significantly more frequent in dogs older than 12 years, but no breed predisposition was observed. The frequency of PEH was significantly higher than that of CEH. The frequency of pyometra in PEH cases was significantly higher than endometritis or uterus without inflammation. This study identified age, breed group, and size as predisposing factors for PEH and further demonstrated the association between this condition and pyometra in dogs.
假胎盘性子宫内膜增生（PEH）和囊性子宫内膜增生（CEH）均为增生性病变，可能在犬发情后期出现在子宫内。CEH会损害生育能力，尽管PEH的后果鲜为人知，但这种情况与子宫蓄脓显著相关。本研究的目的是根据年龄、体型、品种和品种组调查雌性犬中PEH和CEH的发生频率。对300只雌性犬的子宫进行采样并进行组织病理学分析。识别病变，并对发生频率进行统计学比较。PEH在4至12岁的犬中明显更常见，在约克夏犬中比西施犬明显更少见，在包括巴西梗犬和约克夏犬的品种组中也是如此。CEH在12岁以上的犬中明显更常见，但未观察到品种易感性。PEH的发生频率明显高于CEH。PEH病例中子宫蓄脓的发生率明显高于子宫内膜炎或无炎症的子宫。本研究确定年龄、品种组和体型是PEH的易感因素，并进一步证明了这种情况与犬子宫蓄脓之间的关联。
