Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
Top Companion Anim Med. 2022 Jul-Aug;49:100650. doi: 10.1016/j.tcam.2022.100650. Epub 2022 Mar 6.
Staphylococcus pseudintermedius is a commensal bacterium residing on the mucosae and skin surfaces of dogs. Under favorable conditions, the organism may cause serious infections, primarily involving the skin, but it is also isolated in eye and ear infections. This report describes pathologic findings of pyometra associated with S pseudintermedius in two bitches. One bitch was a 6-year-old Pomeranian bitch who died after three days of diarrhea, vomiting, and depression. During necropsy, the uterus of the bitch was diffusely enlarged and filled with 30 mL of thick, yellow, creamy pus. Histology revealed acute to subacute, diffuse, severe, purulent endometritis with intralesional Gram-positive round cocci revealed as S pseudintermedius. The cause of death was pyometra with subsequent septic shock. The other bitch was a 2-year-old West Highland White Terrier who underwent diagnostic laparotomy due to suppurative peritonitis of unknown cause. During the procedure, about 100 mL of yellow, opaque exudate from the abdominal cavity was removed. The distended uterine horns noted during the procedure were removed and submitted for histopathology which revealed necrosis of endometrium with the accumulation of pus and numerous, intralesional S pseudintermedius in the uterine lumen. Focally, uterine wall necrosis was evident, with a spread of bacteria and purulent inflammation into the adjacent mesometrium causing purulent peritonitis. Although S pseudintermedius presents a common cause of skin and mucosal infection, it should be considered a possible etiological agent of canine pyometra.
中间葡萄球菌是一种居住在犬只黏膜和皮肤表面的共生细菌。在有利的条件下，该生物体可能导致严重的感染，主要涉及皮肤，但也分离到眼部和耳部感染。本报告描述了两例与中间葡萄球菌相关的脓性子宫蓄脓的病理发现。一只是 6 岁的博美犬，腹泻、呕吐和抑郁三天后死亡。尸检时，母犬的子宫弥漫性肿大，充满 30 毫升浓稠、黄色、奶油状的脓液。组织学显示急性至亚急性、弥漫性、严重、化脓性子宫内膜炎，病灶内革兰阳性圆形球菌被鉴定为中间葡萄球菌。死亡原因是脓性子宫蓄脓，随后发生败血症性休克。另一只犬是 2 岁的西部高地白梗，因不明原因的化脓性腹膜炎接受了诊断性剖腹手术。手术过程中，从腹腔中取出约 100 毫升黄色、不透明渗出物。手术中发现扩张的子宫角被切除并送检组织病理学检查，结果显示子宫内膜坏死，伴有脓液积聚和大量中间葡萄球菌在子宫腔内。局部可见子宫壁坏死，细菌扩散并伴有化脓性炎症蔓延至相邻的子宫系膜，导致化脓性腹膜炎。虽然中间葡萄球菌是皮肤和黏膜感染的常见原因，但它也应被视为犬脓性子宫蓄脓的可能病因之一。
