Hansson A, Veliz G, Naquira C, Amren M, Arroyo M, Arevalo G
J Ethnopharmacol. 1986 Aug;17(2):105-38. doi: 10.1016/0378-8741(86)90053-x.
Ficus glabrata latex has been a well-known anthelminthic remedy in the neotropical regions since ancient times. The latex has been commercially exploited for decades because of its content of the proteolytic enzyme-complex ficin. A safe dosage regimen with direct use of the latex has been elucidated to control intestinal helminthiasis in the Indian and non-Indian rural population. Helminthiasis was common in three Amazonian villages, field bases for the clinical study, with an overall prevalence of 92%. Specific prevalences were: Ascaris 68%, Strongyloides 42%, Trichuris 41%, Ancylostoma/Necator 26% and Taenia 1%. Variation in the biological activity of the latex was estimated by using a milk coagulating test. Pharmacological studies with live Ascaris demonstrated a lethal effect at concentrations down to 0.05% latex in physiological saline solution. A clinical trial on 181 persons has resulted in a recommended dosage of 1.0 cm3 of prepared latex/kg per day for 3 days to be repeated every 3 months.
自古以来，光滑榕乳胶在新热带地区就是一种著名的驱虫药物。由于其含有蛋白水解酶复合物无花果蛋白酶，这种乳胶已被商业开发了几十年。已经阐明了直接使用乳胶的安全剂量方案，以控制印度和非印度农村人口的肠道蠕虫病。蠕虫病在临床研究的三个亚马逊村庄很常见，总体患病率为92%。具体患病率为：蛔虫68%，粪类圆线虫42%，鞭虫41%，钩虫/板口线虫26%，绦虫1%。通过乳凝试验估计乳胶生物活性的变化。对活蛔虫的药理学研究表明，在生理盐溶液中乳胶浓度低至0.05%时具有致死作用。一项针对181人的临床试验得出的推荐剂量为每天1.0立方厘米制备好的乳胶/千克，持续3天，每3个月重复一次。
