López-Abán Julio, Vicente-Santiago Belén, Gutiérrez-Soto Guadalupe, Rodríguez-Garza Nancy Edith, Kačániová Miroslava, López-Sandin Iosvany, Romo-Sáenz Cesar Iván, Ballesteros-Torres Juan Manuel, Galaviz-Silva Lucio, Castillo-Velázquez Uziel, Garzoli Stefania, Elizondo-Luévano Joel Horacio
Infectious and Tropical Diseases Group (e-INTRO), IBSAL-CIETUS (Biomedical Research Institute of Salamanca-Centre for Tropical Diseases at the University of Salamanca), Faculty of Pharmacy, Universidad de Salamanca, Ldo, Mendez Nieto s/n, 37007 Salamanca, Spain.
Laboratory of Natural Sciences, Biomolecular Innovation Group, Faculty of Agronomy, Campus of Agricultural Sciences, Universidad Autónoma de Nuevo León, Francisco I. Madero s/n, Ex Hacienda el Canada, Cd. Gral. Escobedo 66050, NL, Mexico.
Pathogens. 2025 Aug 23;14(9):842. doi: 10.3390/pathogens14090842.
Strongyloidosis is a parasitic disease caused by , a nematode with a complex life cycle that facilitates long-term persistence within the host. The infection affects millions of people in tropical and subtropical regions and poses a particular challenge in immunocompromised individuals. Although conventional treatments, such as ivermectin and albendazole, are generally effective, emerging concerns regarding drug resistance and adverse effects have prompted the search for alternative therapeutic options. In this context, natural products-including plant extracts, bioactive phytochemicals, and nanoparticle-based formulations derived from natural sources-are emerging as promising anti- potential. This review summarizes recent studies on natural products with anthelmintic activity against strongyloidiasis, with emphasis on their mechanisms of action, efficacy, and future perspectives. A systematic search of the literature was conducted using terms related to , plant species, extracts, and bioactive compounds with nematocidal activity. Eligible studies included those reporting the activity of plants, plant extracts, and their purified metabolites against spp. Data were compiled into a comprehensive table including year of publication, author, plant species, active principle, application conditions, and target nematode species. The pharmacological treatment of this parasite varies according to its life cycle stage. Various biomolecules, phytoactive compounds, and novel plant-based formulations have demonstrated promising activity and may be considered both for treatment and for inclusion in control programs for strongyloidiasis. This review highlights medicinal plants and phytochemicals with ethnopharmacological background and experimentally validated activity against spp., integrating evidence from in vitro, in vivo, and experimental models, as well as clinical trials.
类圆线虫病是由一种线虫引起的寄生虫病，该线虫具有复杂的生命周期，便于在宿主体内长期存活。这种感染影响着热带和亚热带地区的数百万人，对免疫功能低下的个体构成了特殊挑战。尽管伊维菌素和阿苯达唑等传统治疗方法通常有效，但对耐药性和不良反应的新担忧促使人们寻找替代治疗方案。在这种背景下，天然产物——包括植物提取物、生物活性植物化学物质以及源自天然来源的纳米颗粒制剂——正作为有前景的抗类圆线虫病药物出现。本综述总结了近年来关于具有抗类圆线虫病驱虫活性的天然产物的研究，重点关注它们的作用机制、疗效和未来前景。使用与类圆线虫、植物物种、提取物以及具有杀线虫活性的生物活性化合物相关的术语对文献进行了系统检索。符合条件的研究包括那些报告植物、植物提取物及其纯化代谢物对类圆线虫属物种活性的研究。数据被汇编成一个综合表格，包括出版年份、作者、植物物种、活性成分、应用条件和目标线虫物种。这种寄生虫的药物治疗因其生命周期阶段而异。各种生物分子、植物活性化合物和新型植物制剂已显示出有前景的活性，可考虑用于类圆线虫病的治疗和纳入控制计划。本综述重点介绍了具有民族药理学背景且经实验验证对类圆线虫属物种有活性的药用植物和植物化学物质，整合了来自体外、体内和实验模型以及临床试验的证据。
