Stewart Brent W, Keaser Michael L, Lee Hwiyoung, Margerison Sarah M, Cormie Matthew A, Moayedi Massieh, Lindquist Martin A, Chen Shuo, Mathur Brian N, Seminowicz David A
Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.
Department of Epidemiology & Public Health, Maryland Psychiatric Research Center, Catonsville, MD, USA.
bioRxiv. 2023 Nov 2:2023.11.01.564054. doi: 10.1101/2023.11.01.564054.
Aberrant cognitive network activity and cognitive deficits are established features of chronic pain. However, the nature of cognitive network alterations associated with chronic pain and their underlying mechanisms require elucidation. Here, we report that the claustrum, a subcortical nucleus implicated in cognitive network modulation, is activated by acute painful stimulation and pain-predictive cues in healthy participants. Moreover, we discover pathological activity of the claustrum and a lateral aspect of the right dorsolateral prefrontal cortex (latDLPFC) in migraine patients. Dynamic causal modeling suggests a directional influence of the claustrum on activity in this latDLPFC region, and diffusion weighted imaging (DWI) verifies their structural connectivity. These findings advance understanding of claustrum function during acute pain and provide evidence of a possible circuit mechanism driving cognitive impairments in chronic pain.
异常的认知网络活动和认知缺陷是慢性疼痛的既定特征。然而，与慢性疼痛相关的认知网络改变的性质及其潜在机制仍有待阐明。在此，我们报告，在健康参与者中，扣带回（一个参与认知网络调节的皮质下核团）会被急性疼痛刺激和疼痛预测线索激活。此外，我们发现偏头痛患者的扣带回以及右侧背外侧前额叶皮质（latDLPFC）外侧存在病理性活动。动态因果模型表明扣带回对该latDLPFC区域的活动具有定向影响，而扩散加权成像（DWI）证实了它们的结构连接性。这些发现推进了我们对急性疼痛期间扣带回功能的理解，并为驱动慢性疼痛中认知障碍的可能回路机制提供了证据。
