屏状核在认知控制中的作用。
A role for the claustrum in cognitive control.
机构信息
Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA; Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD 21201, USA.
出版信息
Trends Cogn Sci. 2022 Dec;26(12):1133-1152. doi: 10.1016/j.tics.2022.09.006. Epub 2022 Sep 30.
Early hypotheses of claustrum function were fueled by neuroanatomical data and yielded suggestions that the claustrum is involved in processes ranging from salience detection to multisensory integration for perceptual binding. While these hypotheses spurred useful investigations, incompatibilities inherent in these views must be reconciled to further conceptualize claustrum function amid a wealth of new data. Here, we review the varied models of claustrum function and synthesize them with developments in the field to produce a novel functional model: network instantiation in cognitive control (NICC). This model proposes that frontal cortices direct the claustrum to flexibly instantiate cortical networks to subserve cognitive control. We present literature support for this model and provide testable predictions arising from this conceptual framework.
早期关于屏状核功能的假说受到神经解剖学数据的推动，并提出了一些假设，即屏状核参与了从突显检测到多感觉整合的过程，以实现知觉绑定。虽然这些假说激发了有用的研究，但这些观点固有的不兼容性必须加以调和，以便在大量新数据中进一步构想屏状核的功能。在这里，我们回顾了各种屏状核功能模型，并将其与该领域的发展相结合，产生了一个新的功能模型：认知控制中的网络实例化（NICC）。该模型提出，额皮质指导屏状核灵活地实例化皮质网络，以支持认知控制。我们为这个模型提供了文献支持，并提供了这个概念框架所产生的可测试的预测。
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