Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Department of Neurology, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Neurol Res. 2023 Aug;45(8):717-724. doi: 10.1080/01616412.2023.2199377. Epub 2023 Apr 5.
Previous functional magnetic resonance imaging (fMRI) studies reported inconsistent results for comparison in brain activation between migraine patients and healthy controls (HC). Thus, activation likelihood estimation (ALE) method, a powerful voxel-based technique, was used to explore the concordant functional brain changes in migraine patients.
Studies published before October 2022 were searched in the following databases (PubMed, Web of Science and Google Scholar).
Migraine without aura (MWoA) patients showed reduced amplitude of low-frequency fluctuations (ALFF) in right lingual gyrus, the left posterior cingulate and the right precuneus (PCUN), compared to HC. Migraine patients showed increased ALFF in the right claustrum, the left caudate, the left insula and the right parahippocampal gyrus, compared to HC. MWoA patients showed reduced regional homogeneity (ReHo) in the right culmen, compared to HC. In addition, migraine patients showed increased ReHo in the bilateral thalamus, compared to HC. MWoA patients showed reduced whole-brain functional connectivity (FC) in the left middle occipital gyrus and the right superior parietal lobule, compared to HC. In addition, migraine patients showed increased whole-brain FC in the left middle temporal gyrus (MTG), the right inferior frontal gyrus, the right superior temporal gyrus (STG) and the left inferior temporal gyrus, compared to HC.
ALE analysis identified consistent functional changes in widespread regions, especially in cingulate gyrus, basal ganglia region and frontal cortex in migraine. These regions involve in pain processing, cognitive dysfunction and emotional problems. These results may provide important clues for clarifying the pathophysiology of migraine.
先前的功能磁共振成像（fMRI）研究报告称，偏头痛患者与健康对照者（HC）之间的大脑激活比较存在不一致的结果。因此，采用激活似然估计（ALE）方法这一强大的体素基技术，来探索偏头痛患者的一致功能性脑变化。
在以下数据库（PubMed、Web of Science 和 Google Scholar）中搜索截至 2022 年 10 月之前发表的研究。
与 HC 相比，无先兆偏头痛（MWoA）患者右侧舌回、左侧后扣带回和右侧楔前叶的低频波动幅度降低（ALFF）。与 HC 相比，偏头痛患者右侧屏状核、左侧尾状核、左侧岛叶和右侧海马旁回的 ALFF 增加。MWoA 患者右侧穹窿的局部一致性（ReHo）较 HC 降低。此外，与 HC 相比，偏头痛患者双侧丘脑的 ReHo 增加。MWoA 患者左侧中枕叶和右侧顶叶上回的全脑功能连接（FC）较 HC 降低。此外，与 HC 相比，偏头痛患者左侧颞中回（MTG）、右侧额下回、右侧颞上回（STG）和左侧颞下回的全脑 FC 增加。
ALE 分析确定了偏头痛患者广泛区域的一致功能变化，特别是扣带回、基底节和额皮质。这些区域涉及疼痛处理、认知功能障碍和情绪问题。这些结果可能为阐明偏头痛的病理生理学提供重要线索。
