Lupo Center for Aesthetic and General Dermatology, New Orleans, Louisiana.
Cosmetic Laser Dermatology, San Diego, California.
Dermatol Surg. 2024 Jan 1;50(1):81-85. doi: 10.1097/DSS.0000000000003994. Epub 2023 Oct 26.
Acne scarring is an unfortunate sequela affecting up to 95% of patients with acne and carries profound psychosocial impact. Both nonablative fractional lasers (NAFL) and microneedling with radiofrequency (MNRF) have demonstrated comparable efficacy in the treatment of atrophic acne scars.
To determine whether alternating NAFL and MNRF is superior to NAFL alone in the treatment of atrophic acne scars.
This was a prospective, single-center, double-blinded, split-face clinical trial. Twenty patients with atrophic acne scars who had their facial halves randomized to receive either NAFL alone or NAFL alternating with MNRF. Patients received 4 total treatments at 4-week intervals.
Ninety days after the final treatment, both facial halves demonstrated a significant improvement in the mean global échelle d'évaluation clinique des cicatrices d'acné (ECCA) score from baseline ( p < .001 for both halves). The average percentage improvement at the final end point was 20% to 30% from baseline. No significant difference was noted between facial halves for mean global ECCA score or percentage improvement at any time point.
Although both NAFL and MNRF are safe and effective in the treatment of atrophic acne scars, alternating NAFL and MNRF does not seem to be superior to NAFL alone.
痤疮瘢痕是一种不幸的后遗症，影响多达 95%的痤疮患者，并带来深刻的心理社会影响。非剥脱性点阵激光（NAFL）和微针射频（MNRF）在治疗萎缩性痤疮瘢痕方面均显示出相当的疗效。
确定交替使用 NAFL 和 MNRF 是否优于单独使用 NAFL 治疗萎缩性痤疮瘢痕。
这是一项前瞻性、单中心、双盲、分割面的临床试验。20 例萎缩性痤疮瘢痕患者，将其面部随机分为单独接受 NAFL 或 NAFL 与 MNRF 交替治疗。患者每 4 周接受 4 次治疗。
末次治疗后 90 天，两侧面部的平均痤疮瘢痕临床评估量表（ECCA）评分均较基线显著改善（两侧均 p <.001）。最终终点时的平均改善百分比为基线的 20%至 30%。在任何时间点，两侧面部的平均 ECCA 评分或改善百分比均无显著差异。
尽管 NAFL 和 MNRF 均安全有效治疗萎缩性痤疮瘢痕，但交替使用 NAFL 和 MNRF 似乎并不优于单独使用 NAFL。
