Batistella Melania, Santaella Erick, Oliveira Sandra, Maan Claudia, Kopytina Valeria, López Berroa Jorge
Me to Me Clinic, Fiuggi, Italy.
Sapienza University of Rome, Rome, Italy.
Acta Dermatovenerol Alp Pannonica Adriat. 2025 Jun;34(2):65-72.
The integration of active ingredients into scientifically backed formulations is an innovative approach to remodeling post-acne atrophic scars, stimulating regenerative processes. Microneedling, a minimally invasive procedure, promotes collagen production and enhances skin penetration of cosmeceutical products such as Pbserum Specific Acne Scars®, which combines collagenases G and H with hyaluronate r-lyase and other ingredients, including allantoin, zinc sulfate, vitamin A, vitamin B3, niacinamide, and melatonin. These components modulate inflammation, fibrosis, oxidative stress, and aging. This study assesses the efficacy and safety of treatment for ameliorating atrophic acne scars.
Twenty-nine patients were treated with Pbserum Specific Acne Scars® applied by microneedling for 4 months in four sessions on the middle or lower third of the face and/or periocular area. The scar size (according to EvaFace® analysis), deep skin hydration (measured with a Moisturemeter® D device), severity (assessed using the échelle d'évaluation clinique des cicatrices d'acne and Goodman and Baron scales), clinical efficacy (evaluated using Global Aesthetic Improvement Scale), quality of life (measured using Facial Acne Scar Quality of Life questionnaire), and subject satisfaction were analyzed.
Significant improvements were observed in all parameters evaluated, especially after four applications, demonstrating clinical efficacy. Patient satisfaction levels were notably high.
The treatment significantly improved skin texture and scar appearance after four applications over a period of 4 months.
将活性成分整合到科学验证的配方中是重塑痤疮后萎缩性瘢痕、刺激再生过程的一种创新方法。微针疗法是一种微创手术，可促进胶原蛋白生成，并增强美容护肤产品（如Pbserum Specific Acne Scars®）的皮肤渗透，该产品将胶原酶G和H与透明质酸r-裂解酶及其他成分（包括尿囊素、硫酸锌、维生素A、维生素B3、烟酰胺和褪黑素）相结合。这些成分可调节炎症、纤维化、氧化应激和衰老。本研究评估了改善萎缩性痤疮瘢痕治疗的疗效和安全性。
29例患者在面部中下部和/或眼周区域通过微针应用Pbserum Specific Acne Scars®进行治疗，共4个疗程，为期4个月。分析瘢痕大小（根据EvaFace®分析）、深层皮肤水合作用（使用Moisturemeter® D设备测量）、严重程度（使用痤疮瘢痕临床评估量表以及古德曼和巴伦量表进行评估）、临床疗效（使用全球美学改善量表进行评估）、生活质量（使用面部痤疮瘢痕生活质量问卷进行测量）以及患者满意度。
在所有评估参数中均观察到显著改善，尤其是在四次治疗后，显示出临床疗效。患者满意度显著较高。
在4个月的时间内进行四次治疗后，该治疗显著改善了皮肤质地和瘢痕外观。
