Greene E J, Friedman M A, Sherrod J A, Salerno A J
Mutat Res. 1979 May;67(1):9-19. doi: 10.1016/0165-1218(79)90094-6.
Phenylglycidyl ether (1,2-epoxy-3-phenoxy propane) (PGE) was tested for genetic activity in bacterial and mammalian tests. It was active in the Salmonella/microsome mutagenicity test. Concentration-dependent mutagenicity was demonstrated in S. typhimurium strains TA1535 and TA100 with and without rat S9, but not in strains TA98, TA1537, or TA1538. These results suggest PGE, is a direct-acting mutagen causing base substitutions. Phenylglycidyl ether did not induce 6-thioguanine-resistant mutants of Chinese hamster ovary cells, with or without rat S9, and with or without serum in the medium. Dose-dependent enhancement of SA7 virus transformation of primary hamster embryo cells was observed at concentrations of 1.6 microgram/ml and higher. In addition, this compound was able to chemically transform secondary hamster embryo cells at concentrations of 6.2 micrograms/ml and higher. At a dose of 2500 mg/kg p.o., PGE was active in the host-mediated assay using C57B1/6 X C3H mice and S. typhimurium strain TA1535. This activity represented a positive response in 2 of 5 animals tested. Murine testicular DNA synthesis was not inhibited by oral administration of PGE at 500 mg/kg.
苯基缩水甘油醚（1,2-环氧-3-苯氧基丙烷）（PGE）在细菌和哺乳动物试验中接受了遗传活性测试。它在沙门氏菌/微粒体诱变性试验中具有活性。在有或没有大鼠S9的情况下，在鼠伤寒沙门氏菌菌株TA1535和TA100中都证明了浓度依赖性诱变性，但在菌株TA98、TA1537或TA1538中未观察到。这些结果表明PGE是一种导致碱基置换的直接作用诱变剂。苯基缩水甘油醚在有或没有大鼠S9以及培养基中有无血清的情况下，均未诱导中国仓鼠卵巢细胞产生6-硫代鸟嘌呤抗性突变体。在浓度为1.6微克/毫升及更高时，观察到原代仓鼠胚胎细胞的SA7病毒转化呈剂量依赖性增强。此外，该化合物在浓度为6.2微克/毫升及更高时能够化学转化二代仓鼠胚胎细胞。以2500毫克/千克的口服剂量，PGE在使用C57B1/6×C3H小鼠和鼠伤寒沙门氏菌菌株TA1535的宿主介导试验中具有活性。在测试的5只动物中有2只出现了这种活性的阳性反应。口服500毫克/千克的PGE不会抑制小鼠睾丸DNA的合成。
