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二甲双胍和/或他汀类药物治疗对 2 型糖尿病患者体力活动与 HbA1c 相关性的潜在钝化作用。

The potential blunting effect of metformin and/or statin therapy on physical activity-induced associations with HbA1c in type 2 diabetes.

机构信息

NIHR, Leicester Biomedical Research Centre, Leicester, UK.

Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.

出版信息

J Diabetes. 2024 Feb;16(2):e13495. doi: 10.1111/1753-0407.13495. Epub 2023 Nov 14.

DOI:10.1111/1753-0407.13495
PMID:37964490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10859307/
Abstract

Highlights Our analysis indicates a potential blunting effect of metformin and/or statin therapy on physical activity-induced associations with HbA1c. The benefit of daily physical activity on glycemic control in people with type 2 diabetes is potentially more apparent in those prescribed neither metformin nor statin therapy. As physical activity is rarely prescribed in isolation of other background medications used to manage type 2 diabetes, the results of this analysis may help to maximize interventions delivered through routine clinical care, while allowing for personalization in prescribed physical activity and pharmacotherapy.

摘要

研究结果表明，二甲双胍和/或他汀类药物治疗可能会削弱体力活动与糖化血红蛋白之间的关联。对于未接受二甲双胍或他汀类药物治疗的 2 型糖尿病患者，日常体力活动对血糖控制的益处可能更为明显。由于体力活动很少单独开具，而是与其他用于治疗 2 型糖尿病的常规药物联合使用，因此，这项分析的结果可能有助于最大限度地发挥通过常规临床护理提供的干预措施的效果，同时允许根据个人情况调整体力活动和药物治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c10/10859307/c80bc6549131/JDB-16-e13495-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c10/10859307/49ae2cfc106b/JDB-16-e13495-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c10/10859307/c80bc6549131/JDB-16-e13495-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c10/10859307/49ae2cfc106b/JDB-16-e13495-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c10/10859307/c80bc6549131/JDB-16-e13495-g003.jpg

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本文引用的文献

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The interaction between metformin and physical activity on postprandial glucose and glucose kinetics: a randomised, clinical trial.二甲双胍与体力活动对餐后血糖和葡萄糖动力学的相互作用：一项随机临床试验。
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Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the Look AHEAD trial.
二甲双胍治疗是否会影响强化生活方式干预的效果？在 LOOK AHEAD 试验中探索一线治疗方法之间的相互作用。
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Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.二甲双胍抑制老年人有氧运动训练中线粒体的适应性变化。
Aging Cell. 2019 Feb;18(1):e12880. doi: 10.1111/acel.12880. Epub 2018 Dec 11.
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Glucose homeostasis in statin users-The LIFESTAT study.他汀类药物使用者的血糖稳态- LIFESTAT 研究。
Diabetes Metab Res Rev. 2019 Mar;35(3):e3110. doi: 10.1002/dmrr.3110. Epub 2018 Dec 21.
6
Does metformin modify the effect on glycaemic control of aerobic exercise, resistance exercise or both?二甲双胍是否会改变有氧运动、抗阻运动或两者结合对血糖控制的影响？
Diabetologia. 2013 Nov;56(11):2378-82. doi: 10.1007/s00125-013-3026-6. Epub 2013 Aug 23.
7
Simvastatin impairs exercise training adaptations.辛伐他汀会损害运动训练的适应性。
J Am Coll Cardiol. 2013 Aug 20;62(8):709-14. doi: 10.1016/j.jacc.2013.02.074. Epub 2013 Apr 10.
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Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults.二甲双胍改变了运动训练对糖耐量受损成年人心血管疾病危险因素的影响。
Obesity (Silver Spring). 2013 Jan;21(1):93-100. doi: 10.1002/oby.20235.
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Metformin and exercise in type 2 diabetes: examining treatment modality interactions.二甲双胍与 2 型糖尿病患者的运动治疗：探究治疗方式的相互作用。
Diabetes Care. 2011 Jul;34(7):1469-74. doi: 10.2337/dc10-2207. Epub 2011 May 20.
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