钒卤过氧化物酶催化吲哚的脱羧卤化反应。
Decarboxylative halogenation of indoles by vanadium haloperoxidases.
作者信息
Harstad Lauren J, Wells Clare E, Lee Hyung Ji, Ramos Lauren P T, Sharma Manik, Pascoe Cameron A, Biegasiewicz Kyle F
机构信息
School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
Department of Chemistry, Emory University, Atlanta, GA 30322, USA.
出版信息
Chem Commun (Camb). 2023 Nov 30;59(96):14289-14292. doi: 10.1039/d3cc04053d.
Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases are capable of producing 3-haloindoles through decarboxylative halogenation of 3-carboxyindoles. This biocatalytic method is applicable to decarboxylative chlorination, bromination, and iodination in moderate to high yields and with excellent chemoselectivity.
卤代杂芳烃是众多化学工业中的关键构建模块。在此，我们报道钒卤过氧化物酶能够通过3-羧基吲哚的脱羧卤化反应生成3-卤代吲哚。这种生物催化方法适用于脱羧氯化、溴化和碘化反应，产率适中至高，且具有出色的化学选择性。
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