Gu Shanshan, Xu Yun, Zhu Xiaoshu, Lam Anderson, Yi Danhui, Gong Lutian, Wang Jinghui, Guo Xinyu, Fu Li, Shi Jiyan, Wang Feiye, Liu Ketan
Oncology Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
National Institute of Complementary Medicine (NICM) Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Front Oncol. 2023 Oct 26;13:1194673. doi: 10.3389/fonc.2023.1194673. eCollection 2023.
Fatigue is a common source of distress for cancer survivors. The severity of cancer-related fatigue varies significantly, which may be due to individual differences in host factors.
This cross-sectional study aims to explore how demographic, oncological, sociological, psychological, and stress-related hormones levels interact to influence the distinct experiences of fatigue (Cancer-related fatigue [CRF] occurrence and fatigue degree).
A cross-sectional study carried out at the oncology outpatient and ward department of Xiyuan Hospital of China Academy of Chinese Medical Sciences recruited 306 cancer patients between January 2021 to December 2021. General information, fatigue, psychological factors was evaluated by general information questionnaire, the Revised Piper's Fatigue Scale-Chinese Version (RPFS-CV), and the self-report Hospital Anxiety and Depression Scale (HADS). Stress-related hormones were measured with chemiluminescent enzyme immunoassay (Zhengzhou Antobio).
306 patients were included, 229 (74.8%) were diagnosed with CRF, including 94 (41.0%) with mild fatigue, 121 (52.8%) with moderate fatigue, and 14 (6.1%) with severe fatigue. Multivariate regression analysis showed that higher depression scores, aldosterone levels may increase the risk of CRF. Patients who are obese (Body mass index ≥ 28 kg/m) may help to reduce the risk of CRF. Other contributing factors for increased levels of fatigue (< 0.05) include being female, having anxiety, depression and high aldosterone levels.
The research suggested that CRF was a common symptom in cancer survivors and pay attention to these influencing factors may help to better identify patients susceptible to fatigue and provide long-term, targeted interventions.
疲劳是癌症幸存者常见的困扰来源。癌症相关疲劳的严重程度差异很大，这可能归因于宿主因素的个体差异。
这项横断面研究旨在探讨人口统计学、肿瘤学、社会学、心理学和应激相关激素水平如何相互作用，以影响疲劳的不同体验（癌症相关疲劳[CRF]的发生和疲劳程度）。
在中国中医科学院西苑医院肿瘤科门诊和病房进行的一项横断面研究，招募了2021年1月至2021年12月期间的306例癌症患者。通过一般信息问卷、修订版派珀疲劳量表中文版（RPFS-CV）和自评医院焦虑抑郁量表（HADS）评估一般信息、疲劳和心理因素。采用化学发光酶免疫分析法（郑州安图生物）检测应激相关激素。
纳入306例患者，229例（74.8%）被诊断为CRF，其中轻度疲劳94例（41.0%），中度疲劳121例（52.8%），重度疲劳14例（6.1%）。多因素回归分析显示，抑郁评分较高、醛固酮水平可能增加CRF的风险。肥胖（体重指数≥28kg/m）患者可能有助于降低CRF的风险。疲劳水平升高的其他影响因素（<0.05）包括女性、焦虑、抑郁和醛固酮水平升高。
研究表明，CRF是癌症幸存者的常见症状，关注这些影响因素可能有助于更好地识别易疲劳患者，并提供长期、有针对性的干预措施。
