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SMPDL3A links cholesterol metabolism to the cGAS-STING pathway.
Immunity. 2023 Nov 14;56(11):2459-2461. doi: 10.1016/j.immuni.2023.10.015.
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SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
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cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans.
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Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases.
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Advances in structure-guided mechanisms impacting on the cGAS-STING innate immune pathway.
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DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.
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The cGAS-STING Pathway: Novel Perspectives in Liver Diseases.
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The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism.
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Deciphering cGAS-STING signaling: implications for tumor immunity and hepatocellular carcinoma.
Naunyn Schmiedebergs Arch Pharmacol. 2025 May 7. doi: 10.1007/s00210-025-04240-6.
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Multiomics analysis provides insights into musk secretion in muskrat and musk deer.
Gigascience. 2025 Jan 6;14. doi: 10.1093/gigascience/giaf006.
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Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs.
EMBO Rep. 2025 Jan;26(2):560-592. doi: 10.1038/s44319-024-00346-9. Epub 2024 Dec 12.
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The crucial roles and research advances of cGAS‑STING pathway in liver diseases.
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本文引用的文献

1
SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
Immunity. 2023 Nov 14;56(11):2492-2507.e10. doi: 10.1016/j.immuni.2023.10.001. Epub 2023 Oct 26.
2
Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway.
Annu Rev Biochem. 2022 Jun 21;91:599-628. doi: 10.1146/annurev-biochem-040320-101629. Epub 2022 Mar 14.
3
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Nat Rev Immunol. 2021 Sep;21(9):548-569. doi: 10.1038/s41577-021-00524-z. Epub 2021 Apr 8.
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Systemic Immunometabolism: Challenges and Opportunities.
Immunity. 2020 Sep 15;53(3):496-509. doi: 10.1016/j.immuni.2020.08.012.
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Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.
Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.
6
Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.
Nat Chem Biol. 2014 Dec;10(12):1043-8. doi: 10.1038/nchembio.1661. Epub 2014 Oct 26.
8
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20.
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Liver x receptors in atherosclerosis and inflammation.
Circ Res. 2011 Apr 15;108(8):996-1001. doi: 10.1161/CIRCRESAHA.110.226878.

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