Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Immunity. 2023 Nov 14;56(11):2459-2461. doi: 10.1016/j.immuni.2023.10.015.
Liver X receptor (LXR), well known for its role in cholesterol metabolism, also has anti-inflammatory properties. In this issue of Immunity, Hou et al. demonstrate that LXR signaling induces SMPDL3A, a cGAMP-degrading enzyme that restricts cGAS-cGAMP-STING innate immune signaling, providing a mechanistic link between lipid metabolism and inflammation.
肝 X 受体 (LXR) 以其在胆固醇代谢中的作用而闻名,也具有抗炎特性。在本期《免疫》中,Hou 等人证明 LXR 信号诱导 SMPDL3A 的表达,SMPDL3A 是一种 cGAMP 降解酶,可限制 cGAS-cGAMP-STING 先天免疫信号,为脂质代谢与炎症之间提供了一种机制联系。