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Effect of barbiturates on release endogenous amino acids from rat cortex slices.

作者信息

Cutler R W, Young J

出版信息

Neurochem Res. 1979 Jun;4(3):319-29. doi: 10.1007/BF00963802.

DOI:10.1007/BF00963802
PMID:379676
Abstract

The potassium-stimulated, calcium-dependent release of endogenous GABA and glutamic acid was suppressed by pentobarbital. The ouabain and veratridine-stimulated fluxes of the amino acids, calcium-independent processes, were not suppressed by pentobarbital. Release of GABA and glutamic acid was not suppressed by pentobarbital in the presence of the calcium ionophore A23187. Of eight barbiturates studied at equimolar concentrations six were found to inhibit GABA release. Thiopental was the most potent, and phenobarbital and secobarbital were inactive.

摘要

相似文献

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本文引用的文献

1
Release and exchange of neurotransmitters in synaptosomes: Effects of the ionophore A23187 and of ouabain.在突触小体中神经递质的释放和交换：离子载体 A23187 和哇巴因的作用。
Neurochem Res. 1976 Aug;1(4):409-16. doi: 10.1007/BF00966232.
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PHARMACOLOGICAL STUDIES ON PRESYNAPTIC INHIBITION.突触前抑制的药理学研究
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Microanalysis of amino acids and their determination in biological material using dansyl chloride.使用丹磺酰氯对生物材料中的氨基酸进行微量分析及其测定
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The effects of anaesthetics on the uptake and release of amino acid neurotransmitters in thalamic slices.麻醉剂对丘脑切片中氨基酸神经递质摄取和释放的影响。
Br J Pharmacol. 1982 Jan;75(1):219-27. doi: 10.1111/j.1476-5381.1982.tb08776.x.
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Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro.新生大鼠体外半横断脊髓中谷氨酸受体非NMDA亚型的药理学特性
Br J Pharmacol. 1992 Jun;106(2):367-72. doi: 10.1111/j.1476-5381.1992.tb14342.x.
Hoppe Seylers Z Physiol Chem. 1972 Apr;353(4):540-53. doi: 10.1515/bchm2.1972.353.1.540.
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The effects of anaesthetics on synaptic excitation and inhibition in the olfactory bulb.麻醉剂对嗅球中突触兴奋和抑制的影响。
J Physiol. 1972 Jun;223(3):803-14. doi: 10.1113/jphysiol.1972.sp009875.
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Effects of anesthetics on sodium uptake into rat brain cortex in vitro.麻醉剂对大鼠大脑皮层体外摄取钠的影响。
Biochem Pharmacol. 1972 Jun 15;21(12):1763-73. doi: 10.1016/0006-2952(72)90083-4.
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Locations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids.大鼠脑切片中氨基酸的位置。氨基酸的河豚毒素敏感性释放。
Biochem J. 1972 Jul;128(3):631-46. doi: 10.1042/bj1280631.
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Sodium ion movements and the spontaneous and electrically stimulated release of ( 3 H)GABA and ( 14 C)glutamic acid from rat cortical slices.钠离子运动以及大鼠皮层切片中（3H）γ-氨基丁酸和（14C）谷氨酸的自发释放和电刺激释放。
Brain Res. 1972 Dec 12;47(2):410-3. doi: 10.1016/0006-8993(72)90648-8.
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Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat.荷包牡丹碱，一种γ-氨基丁酸拮抗剂，可抑制猫脊髓中的突触。
Brain Res. 1971 Sep 10;32(1):69-96. doi: 10.1016/0006-8993(71)90156-9.
9
Pharmacological evidence for GABA as the transmitter in granule cell inhibition in the olfactory bulb.γ-氨基丁酸（GABA）作为嗅球颗粒细胞抑制性神经递质的药理学证据。
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The selective depression of evoked cortical EPSPs by pentobarbitone.戊巴比妥对诱发的皮层兴奋性突触后电位的选择性抑制作用。
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