Cutler R W, Young J
Brain Res. 1979 Jul 6;170(1):157-63. doi: 10.1016/0006-8993(79)90947-8.
Penicillin is known to block the depressant action of GABA on cortical and spinal neurons. In this study we examined the effect of penicillin on the release of endogenous amino acids from rat cerebral cortex slices. The principal finding was that penicillin blocked the potassium-stimulated release of GABA, a calcium-dependent process. It did not block the veratridine-stimulated release of GABA, a calcium-independent process. It did not affect the release of other putative transmitter amino acids. Inhibition of GABA release from nerve endings may explain in part the ability of penicillin to depress synaptic inhibitory mechanisms.
已知青霉素可阻断γ-氨基丁酸（GABA）对皮质和脊髓神经元的抑制作用。在本研究中，我们检测了青霉素对大鼠大脑皮质切片内源性氨基酸释放的影响。主要发现是青霉素阻断了钾离子刺激的GABA释放，这是一个依赖钙的过程。它并未阻断藜芦碱刺激的GABA释放，这是一个不依赖钙的过程。它不影响其他假定的递质氨基酸的释放。抑制神经末梢释放GABA可能部分解释了青霉素抑制突触抑制机制的能力。
