Laboratory of Practical Pharmacy, Graduate School and Faculty of Pharmaceutical Sciences, Chiba University.
Laboratory of Clinical Pharmaceutics, Faculty of Pharma-Science, Teikyo University.
Biol Pharm Bull. 2024 Jan 1;47(1):112-119. doi: 10.1248/bpb.b23-00530. Epub 2023 Nov 16.
Overdose has become a global social problem. The Japanese government requires gatekeeper training to detect and prevent indicators of overdose and suicide. However, knowledge of necessary factors for the gatekeeper of overdose (patient intervention) is limited. This study aimed to investigate the characteristics of individuals who experienced intervening persons expected to overdose, and to identify the factors required of gatekeepers. A Google form was used to survey 298 pharmacists and registered sellers in Japan. We searched for factors by logistic analysis. Knowledge of prescription drugs used for overdose was higher among pharmacists than among registered sellers. Conversely, pharmacists and registered sellers had similar knowledge about OTC drugs. Overall multivariate logistic regression analysis revealed countermeasures against overdose at their workplace (odds ratio (OR): 4.01, 95% confidence interval (CI): 2.25-7.15, p < 0.01) and knowledge that overdose is on the rise (OR: 1.93, 95% CI: 1.04-3.69, p < 0.05) to be significantly associated with intervention experience as a gatekeeper. Countermeasures against overdose at their workplace (OR: 2.40, 95% CI: 1.10-5.25, p < 0.05) in pharmacists and years of work experience (OR: 1.13, 95% CI: 1.04-1.24, p < 0.05), countermeasure against overdose at their workplace (OR: 3.43, 95% CI: 1.18-10.0, p < 0.05), and willingness to participate in study sessions and workshops on overdose (OR: 3.50, 95% CI: 1.51-8.10, p < 0.05) in registered seller were significantly associated with intervention experience as a gatekeeper. These results are useful evidences for countermeasures and gatekeeper training for overdose at pharmacies and drugstores in the community.
过量用药已成为全球性的社会问题。日本政府要求看门人培训以发现和预防过量用药和自杀的指标。然而,对于过量用药的看门人(患者干预)所需的必要因素的知识有限。本研究旨在调查经历过预期过量用药的干预者的个体特征,并确定看门人所需的因素。我们使用 Google 表单调查了日本 298 名药剂师和注册销售商。我们通过逻辑分析来寻找因素。药剂师对用于过量用药的处方药物的了解高于注册销售商。相反,药剂师和注册销售商对 OTC 药物的了解相似。总体多变量逻辑回归分析显示,在工作场所采取的针对过量用药的对策(优势比(OR):4.01,95%置信区间(CI):2.25-7.15,p < 0.01)和了解到过量用药呈上升趋势(OR:1.93,95% CI:1.04-3.69,p < 0.05)与作为看门人进行干预的经验显著相关。在药剂师中,在工作场所采取的针对过量用药的对策(OR:2.40,95% CI:1.10-5.25,p < 0.05)和工作年限(OR:1.13,95% CI:1.04-1.24,p < 0.05)、在工作场所采取的针对过量用药的对策(OR:3.43,95% CI:1.18-10.0,p < 0.05)和愿意参加过量用药的学习课程和研讨会(OR:3.50,95% CI:1.51-8.10,p < 0.05)与作为看门人进行干预的经验显著相关。这些结果为社区内的药店和药房针对过量用药采取对策和进行看门人培训提供了有用的证据。